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Daphnetin

CAS No. 486-35-1

Daphnetin ( 7,8-Dihydroxycoumarin; NSC 633563 )

Catalog No. M14627 CAS No. 486-35-1

Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.

Purity : >98%(HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Daphnetin
  • Note
    Research use only, not for human use.
  • Brief Description
    Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.
  • Description
    Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.
  • Synonyms
    7,8-Dihydroxycoumarin; NSC 633563
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR; PKA; PKC
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    486-35-1
  • Formula Weight
    178.14
  • Molecular Formula
    C9H6O4
  • Purity
    >98%(HPLC)
  • Solubility
    DMSO: 35 mg/mL (196.47 mM)
  • SMILES
    O=C1C=CC2=CC=C(O)C(O)=C2O1
  • Chemical Name
    7,8-dihydroxy-2H-1-benzopyran-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yang EB, et al. Biochem Biophys Res Commun, 1999, 260(3), 682-685.
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