AZD-5438

CAS No. 602306-29-6

AZD-5438 ( AZD 5438;AZD5438 )

Catalog No. M15245 CAS No. 602306-29-6

A potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively; also inhibits the kinase activity of p25-Cdk5 (IC50=14 nM) and GSK-3β (IC50=17 nM) in vitro.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 40 In Stock
10MG 57 In Stock
25MG 102 In Stock
50MG 170 In Stock
100MG 308 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    AZD-5438
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively; also inhibits the kinase activity of p25-Cdk5 (IC50=14 nM) and GSK-3β (IC50=17 nM) in vitro.
  • Description
    A potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively; also inhibits the kinase activity of p25-Cdk5 (IC50=14 nM) and GSK-3β (IC50=17 nM) in vitro, displays 75-fold less active against cyclin D-Cdk4; shows significant antiproliferative activity in human tumor cell lines (IC50 range: 0.2-1.7 uM), inhibits the phosphorylation of Cdk substrates pRb, nucleolin, PP1A, and RNA polymerase II COOH-terminal domain and blocks cell cycle; inhibits the human tumor xenograft growth in vivo; also inhibits PASTA kinase in L. monocytogenes (PrkA) and L. monocytogenes growth in a β-lactam-synergism-dependent manner.Solid Tumors Phase 1 Discontinued
  • Synonyms
    AZD 5438;AZD5438
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK1;CDK2;CDK9
  • Research Area
    Cancer
  • Indication
    Solid Tumors

Chemical Information

  • CAS Number
    602306-29-6
  • Formula Weight
    371.46
  • Molecular Formula
    C18H21N5O2S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=S(C1=CC=C(NC2=NC=CC(C3=CN=C(C)N3C(C)C)=N2)C=C1)(C)=O
  • Chemical Name
    2-Pyrimidinamine, 4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Byth KF, et al. Mol Cancer Ther. 2009 Jul;8(7):1856-66.
2. Boss DS, et al. Ann Oncol. 2010 Apr;21(4):884-94.
3. Pensinger DA, et al. Antimicrob Agents Chemother. 2014 Aug;58(8):4486-94.
4. Raghavan P, et al. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-14.
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