AZD-5438

CAS No. 602306-29-6

AZD-5438 ( AZD 5438;AZD5438 )

Catalog No. M15245 CAS No. 602306-29-6

A potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively; also inhibits the kinase activity of p25-Cdk5 (IC50=14 nM) and GSK-3β (IC50=17 nM) in vitro.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 40 In Stock
10MG 57 In Stock
25MG 102 In Stock
50MG 170 In Stock
100MG 308 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    AZD-5438
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively; also inhibits the kinase activity of p25-Cdk5 (IC50=14 nM) and GSK-3β (IC50=17 nM) in vitro.
  • Description
    A potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively; also inhibits the kinase activity of p25-Cdk5 (IC50=14 nM) and GSK-3β (IC50=17 nM) in vitro, displays 75-fold less active against cyclin D-Cdk4; shows significant antiproliferative activity in human tumor cell lines (IC50 range: 0.2-1.7 uM), inhibits the phosphorylation of Cdk substrates pRb, nucleolin, PP1A, and RNA polymerase II COOH-terminal domain and blocks cell cycle; inhibits the human tumor xenograft growth in vivo; also inhibits PASTA kinase in L. monocytogenes (PrkA) and L. monocytogenes growth in a β-lactam-synergism-dependent manner.Solid Tumors Phase 1 Discontinued
  • Synonyms
    AZD 5438;AZD5438
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK1;CDK2;CDK9
  • Research Area
    Cancer
  • Indication
    Solid Tumors

Chemical Information

  • CAS Number
    602306-29-6
  • Formula Weight
    371.46
  • Molecular Formula
    C18H21N5O2S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=S(C1=CC=C(NC2=NC=CC(C3=CN=C(C)N3C(C)C)=N2)C=C1)(C)=O
  • Chemical Name
    2-Pyrimidinamine, 4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Byth KF, et al. Mol Cancer Ther. 2009 Jul;8(7):1856-66.
2. Boss DS, et al. Ann Oncol. 2010 Apr;21(4):884-94.
3. Pensinger DA, et al. Antimicrob Agents Chemother. 2014 Aug;58(8):4486-94.
4. Raghavan P, et al. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-14.
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