AZD-5438
CAS No. 602306-29-6
AZD-5438 ( AZD 5438;AZD5438 )
Catalog No. M15245 CAS No. 602306-29-6
A potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively; also inhibits the kinase activity of p25-Cdk5 (IC50=14 nM) and GSK-3β (IC50=17 nM) in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 40 | In Stock |
|
10MG | 57 | In Stock |
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25MG | 102 | In Stock |
|
50MG | 170 | In Stock |
|
100MG | 308 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZD-5438
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively; also inhibits the kinase activity of p25-Cdk5 (IC50=14 nM) and GSK-3β (IC50=17 nM) in vitro.
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DescriptionA potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively; also inhibits the kinase activity of p25-Cdk5 (IC50=14 nM) and GSK-3β (IC50=17 nM) in vitro, displays 75-fold less active against cyclin D-Cdk4; shows significant antiproliferative activity in human tumor cell lines (IC50 range: 0.2-1.7 uM), inhibits the phosphorylation of Cdk substrates pRb, nucleolin, PP1A, and RNA polymerase II COOH-terminal domain and blocks cell cycle; inhibits the human tumor xenograft growth in vivo; also inhibits PASTA kinase in L. monocytogenes (PrkA) and L. monocytogenes growth in a β-lactam-synergism-dependent manner.Solid Tumors Phase 1 Discontinued
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SynonymsAZD 5438;AZD5438
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK1;CDK2;CDK9
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number602306-29-6
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Formula Weight371.46
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Molecular FormulaC18H21N5O2S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=S(C1=CC=C(NC2=NC=CC(C3=CN=C(C)N3C(C)C)=N2)C=C1)(C)=O
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Chemical Name2-Pyrimidinamine, 4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Byth KF, et al. Mol Cancer Ther. 2009 Jul;8(7):1856-66.
2. Boss DS, et al. Ann Oncol. 2010 Apr;21(4):884-94.
3. Pensinger DA, et al. Antimicrob Agents Chemother. 2014 Aug;58(8):4486-94.
4. Raghavan P, et al. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-14.
2. Boss DS, et al. Ann Oncol. 2010 Apr;21(4):884-94.
3. Pensinger DA, et al. Antimicrob Agents Chemother. 2014 Aug;58(8):4486-94.
4. Raghavan P, et al. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-14.
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