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Palbociclib
CAS No. 571190-30-2
Palbociclib ( PD0332991;PD-0332991;PD 0332991 )
Catalog No. M15082 CAS No. 571190-30-2
A potent and selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM; no inhibition for CDK2A (IC50>5 uM); inhibits MDA-MB453 cells with IC50 of 0.16 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 43 | In Stock |
|
| 10MG | 61 | In Stock |
|
| 50MG | 80 | In Stock |
|
| 100MG | 87 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePalbociclib
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM; no inhibition for CDK2A (IC50>5 uM); inhibits MDA-MB453 cells with IC50 of 0.16 uM.
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DescriptionA potent and selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM; no inhibition for CDK2A (IC50>5 uM); inhibits MDA-MB453 cells with IC50 of 0.16 uM; shows antiproliferative effect against retinoblastoma (Rb)-positive tumor cells in vitro and reduces the phospho-Ser780/Ser795 on the Rb protein; orally bioavailable.Breast Cancer Approved
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SynonymsPD0332991;PD-0332991;PD 0332991
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK4;CDK6
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number571190-30-2
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Formula Weight447.53
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Molecular FormulaC24H29N7O2
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Purity>98% (HPLC)
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SolubilityDMSO: 0.2 mg/mL (Need ultrasonic or warming)
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SMILESCC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N3CCNCC3)N=C2N(C2CCCC2)C1=O
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Chemical NamePyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Toogood PL, et al. J Med Chem. 2005 Apr 7;48(7):2388-406.
2. Fry DW, et al. Mol Cancer Ther. 2004 Nov;3(11):1427-38.
3. Baughn LB, et al. Cancer Res. 2006 Aug 1;66(15):7661-7.
2. Fry DW, et al. Mol Cancer Ther. 2004 Nov;3(11):1427-38.
3. Baughn LB, et al. Cancer Res. 2006 Aug 1;66(15):7661-7.
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