AZD-4573 ( AZD4573 )

Catalog No. M13197 CAS No. 2057509-72-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AZD-4573
Note

Research use only, not for human use.
Brief Description

AZD-4573 (AZD4573) is a potent and selective inhibitor of CDK9, with fast-off binding kinetics and high selectivity versus other kinases, including other CDK family kinases.
Description

AZD-4573 (AZD4573) is a potent and selective inhibitor of CDK9, with fast-off binding kinetics and high selectivity versus other kinases, including other CDK family kinases; AZD4573 exhibits a short half-life in multiple preclinical species and good solubility for intravenous administration; dose- and time-dependently decreases cellular pSer2-RNAPII, resulting in activation of caspase 3 and cell apoptosis in a broad range of haematological cancer cell lines; demonstrates in vivo efficacyin xenograft models derived from multiple haematological tumours.Liver Cancer Phase 1 Clinical
Synonyms

AZD4573
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

Cancer
Indication

Liver Cancer

CAS Number

2057509-72-3
Formula Weight

429.95
Molecular Formula

C22H28ClN5O2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 125 mg/mL 290.74 mM
SMILES

CC(=O)NC1CCCC(C1)C(=O)NC2=NC=C(C(=C2)C3=C4CC(CN4N=C3)(C)C)Cl
Chemical Name

(1S,3R)-3-acetamido-N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl)cyclohexane-1-carboxamide