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AZD-1979

CAS No. 1254035-84-1

AZD-1979( AZD1979 | AZD 1979 )

Catalog No. M11025 CAS No. 1254035-84-1

A potent, selective melanin concentrating hormone receptor 1 (MCH-R1) antagonist with binding Ki of 12.2 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZD-1979
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective melanin concentrating hormone receptor 1 (MCH-R1) antagonist with binding Ki of 12.2 nM.
  • Description
    A potent, selective melanin concentrating hormone receptor 1 (MCH-R1) antagonist with binding Ki of 12.2 nM; shows no apparent affinity for MCHR2 (Ki>40 uM); dose-dependently reduces body weight in DIO mice leading to improved homeostasis model assessment-index of insulin sensitivity.Obesity Phase 1 Clinical.
  • In Vitro
    ——
  • In Vivo
    In DIO mice, initial AZD1979-mediate body weight loss is driven by decreasing food intake, but an additional component of preserving energy expenditure is apparent in pair-feeding and indirect calorimetry studies. AZD1979 also dose-dependently reduces body weight in dogs.
  • Synonyms
    AZD1979 | AZD 1979
  • Pathway
    GPCR/G Protein
  • Target
    MCHR
  • Recptor
    MCHR
  • Research Area
    Metabolic Disease
  • Indication
    Obesity

Chemical Information

  • CAS Number
    1254035-84-1
  • Formula Weight
    462.506
  • Molecular Formula
    C25H26N4O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 33.33 mg/mL (72.06 mM)
  • SMILES
    O=C(N1CC(OC2=CC=C(CN(C3)CC43COC4)C=C2)C1)C5=NN=C(C6=CC=C(OC)C=C6)O5
  • Chemical Name
    (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Johansson A, et al. J Med Chem. 2016 Mar 24;59(6):2497-511. 2. Ploj K, et al. Br J Pharmacol. 2016 Sep;173(18):2739-51.
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