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Home - Products - Membrane Transporter/Ion Channel - Sodium Channel - AZD-1305

AZD-1305

CAS No. 872045-91-5

AZD-1305( AZD1305 )

Catalog No. M16340 CAS No. 872045-91-5

AZD-1305 is a novel antiarrhythmic agent that predominantly blocks the rapid component of Ikr.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZD-1305
  • Note
    Research use only, not for human use.
  • Brief Description
    AZD-1305 is a novel antiarrhythmic agent that predominantly blocks the rapid component of Ikr.
  • Description
    AZD-1305 is a novel antiarrhythmic agent that predominantly blocks the rapid component of IKr, the L-type calcium current, and the inward sodium current in mammalian cells and ventricular cardiomyocytes; significantly prolongs action potential duration and reduces excitability at 0.1-10 uM in dogs, effectively prevents induction of persistent acetylcholine-mediated atrial fibrillation (AF) in vivo.Heart Arrhythmia Phase 1 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AZD1305
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    Sodium Channel
  • Research Area
    Cardiovascular Disease
  • Indication
    Heart Arrhythmia

Chemical Information

  • CAS Number
    872045-91-5
  • Formula Weight
    434.512
  • Molecular Formula
    C22H31FN4O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)(C)OC(=O)NCCN1C[C@@H]2CN(C[C@H](C1)O2)CCOc3ccc(cc3F)C#N
  • Chemical Name
    (2-(7-(2-(4-Cyano-2-fluorophenoxy)ethyl)-9-oxa-3,7-diazabicyclo(3.3.1)non-3-yl)ethyl)carbamic acid tert-butyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sicouri S, et al. J Pharmacol Exp Ther. 2010 Jul;334(1):255-9. 2. Burashnikov A, et al. J Cardiovasc Pharmacol. 2010 Jul;56(1):80-90. 3. Johnson DM, et al. Circ Arrhythm Electrophysiol. 2012 Feb;5(1):201-9. 4. Geller JC, et al. J Clin Pharmacol. 2009 Mar;49(3):312-22.
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