DS-1971a( —— )

Catalog No. M28831 CAS No. 1450595-86-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DS-1971a
Note

Research use only, not for human use.
Brief Description

DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.
Description

DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.(In Vitro):DS-1971a showed high NaV1.7 inhibitory potency in vitro. The IC50 values are of 22.8 nM for hNaV1.7 and 59.4 mM for mNaV1.7.(In Vivo):DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice with ED50 of 0.32 mg/kg.
In Vitro

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In Vivo

DS-1971a exhibits a favorable toxicological profile.DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice. Animal Model:Male Slc:ddY mice (PSL model)Dosage:0.1, 0.3, and 1 mg/kg Administration:P.o.Result:A significant dose-dependent suppression of thermal hyperalgesiain 0.3 and 1 mg/kg administered groups. The ED50 of DS-1971a at the peak efficacy was 0.32 mg/kg.
Synonyms

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Pathway

Membrane Transporter/Ion Channel
Target

Sodium Channel
Recptor

AChE
Research Area

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Indication

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1.Yu S S , Yu D Q , Liang X T . Triterpenoid saponins from the roots of Aralia spinifolia.[J]. Journal of Natural Products, 1994, 57(7):978.

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