AZ6197 ( AZ 6197;AZ-6197 )

Catalog No. M13150 CAS No. 2023003-94-1

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Datasheet

HNMR

HPLC

MSDS

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Product Name

AZ6197
Note

Research use only, not for human use.
Brief Description

AZ6197 (AZ-6197) is a potent, selective, reversible inhibitor of ERK1/2 with IC50 of <0.3 nM (ERK2).
Description

AZ6197 (AZ-6197) is a potent, selective, reversible inhibitor of ERK1/2 with IC50 of <0.3 nM (ERK2), inhibits pERK/pRSK with IC50 of 12/62 nM in A375 cells, respectively; demonstrates in vivo antitumor efficacy.
Synonyms

AZ 6197;AZ-6197
Pathway

MAPK/ERK Signaling
Target

ERK
Recptor

ERK
Research Area

——
Indication

——

CAS Number

2023003-94-1
Formula Weight

442.53
Molecular Formula

C24H26N8O
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1CN2C=C(C=C2C(=O)N1CC3=CC=CC(=N3)C)C4=NC(=NC=C4C)NC5=CC=NN5C
Chemical Name

(R)-3-Methyl-7-(5-methyl-2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-2-((6-methylpyridin-2-yl)methyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

1. Ward RA, et al. J Med Chem. 2017 Apr 27;60(8):3438-3450.
2. Decaudin D, et al. Oncotarget. 2018 Apr 24;9(31):21674-21686.

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