Muramyl dipeptide

Research use only, not for human use.

Muramyl dipeptide is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln.

Muramyl dipeptide is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation through a decreased RANKL/OPG ratio. Muramyl dipeptide directly increases osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2 .

Western Blot Analysis Cell Line:MC3T3-E1 cells Concentration:0.1, 1, 10 μg/mL Incubation Time:24 hours Result:Increased protein expression of Runx2 in a dose-dependent manner.RT-PCR Cell Line:MC3T3-E1 cells Concentration:0.1, 1, 10 μg/mL Incubation Time:6 hours Result:Increases mRNA levels of Runx2 in a dose-dependent manner.

Animal Model:RANKL-induced osteoporosis model (Five-week-old C57BL/6 mice)Dosage:1.25 mg/kg Administration: i.p.; twice (RANKL-induced osteoporosis for 3 weeks and euthanized at 4 weeks)Result:Significantly enhanced the trabecular bone volume (BV/TV) and trabecular number (Tb.N).

MDP

MAPK/ERK Signaling

ERK

ERK|JNK|p38 MAPK

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53678-77-6

492.48

C19H32N4O11

>98% (HPLC)

DMSO:98 mg/mL (198.99 mM);Water:98 mg/mL (198.99 mM)

CC(N[C@@H]1[C@@H](OC(C(N[C@H](C(N[C@H](CCC(O)=O)C(N)=O)=O)C)=O)C)[C@H](O)[C@@H](CO)O[C@@H]1O)=O

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(-20℃)

With Ice Pack

≥ 2 years