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AZ3976
CAS No. 1418747-15-5
AZ3976( —— )
Catalog No. M33968 CAS No. 1418747-15-5
AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 53 | Get Quote |
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| 5MG | 77 | Get Quote |
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| 10MG | 123 | Get Quote |
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| 25MG | 224 | Get Quote |
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| 50MG | 334 | Get Quote |
|
| 100MG | 484 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAZ3976
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NoteResearch use only, not for human use.
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Brief DescriptionAZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.
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DescriptionAZ3976 is a potent plasminogen activator inhibitor type 1 (PAI-1) inhibitor with an IC50?value of 26 μM?in an enzymatic chromogenic assay. AZ3976 is active with an IC50?of 16 μM in a plasma clot lysis assay.?AZ3976 does not bind to active PAI-1 but bound reversibly to latent PAI-1. AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1. AZ3976 displays profibrinolytic activities in a human plasma clot lysis assay.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPAI-1
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RecptorPAI-1
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Research Area——
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Indication——
Chemical Information
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CAS Number1418747-15-5
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Formula Weight317.34
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Molecular FormulaC15H19N5O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (315.12 mM; Ultrasonic )
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SMILESO=C1C=2C(NC(NC3CN(C(OC(C)(C)C)=O)C3)=N1)=NC=CC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ola Fjellstr?m, et al. Characterization of a small molecule inhibitor of plasminogen activator inhibitor type 1 that accelerates the transition into the latent conformation. J Biol Chem. 2013 Jan 11;288(2):873-85.?
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