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Home - Products - GPCR/G Protein - Prostaglandin Receptor - AZ-1355

AZ-1355

CAS No. 75451-07-9

AZ-1355( —— )

Catalog No. M33202 CAS No. 75451-07-9

AZ-1355 is a novel dibenzoxepine derivative with lipid-lowering properties.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZ-1355
  • Note
    Research use only, not for human use.
  • Brief Description
    AZ-1355 is a novel dibenzoxepine derivative with lipid-lowering properties.
  • Description
    AZ-1355 is an effctive lipid-lowering compound, which also inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro.
  • In Vitro
    ——
  • In Vivo
    AZ-1355 (50 mg/kg) significantly reduces serum TG and the 100 mg/kg dose results in serum TC and TG reduction in rat. AZ-1355 (100 mg/kg) reduces total liver TC in rats fed CE-2, and the 50 mg/kg dose reduces hepatic TC in rats fed the high fat diet on both bases, and it also reduces the total hepatic TG of the CE-2 fed rats. AZ-1355 (150 mg/kg) reproducibly lowers serum total cholesterol (TC) in the Triton hyperlipidemic mice.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Prostaglandin Receptor
  • Recptor
    Prostaglandin Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    75451-07-9
  • Formula Weight
    299.32
  • Molecular Formula
    C17H17NO4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O(C)C1=C2C(CNC=3C(O2)=CC=C(C(OCC)=O)C3)=CC=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wada S, et al. The lipid-lowering profile in rodents. AZ-1355, a new dibenzoxazepine derivative. Atherosclerosis. 1981 Nov-Dec;40(3-4):263-71.?
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