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Home - Products - GPCR/G Protein - Prostaglandin Receptor - L-161982

L-161982

CAS No. 147776-06-5

L-161982( —— )

Catalog No. M26732 CAS No. 147776-06-5

L-161982 is a selective antagonist of the EP4 receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    L-161982
  • Note
    Research use only, not for human use.
  • Brief Description
    L-161982 is a selective antagonist of the EP4 receptor.
  • Description
    L-161982 is a selective antagonist of the EP4 receptor.(In Vitro):In squamous carcinoma Tca8113 cells, L-161982 induces apoptosis and cell cycle arrest, and inhibits prostaglandin E2-induced proliferation . L-161982 (10 μM) blocks PGE2-stimulated cell proliferation of HCA-7 cells and ERK phosphorylation.(In Vivo):In collagen-induced arthritis (CIA) mice model, L-161982 (5 mg/kg; i.p.) reduces arthritis lesions and lesion progression. L-161982 shows less joint swelling and lower arthritis score after 35 days post immunization.
  • In Vitro
    L-161982 (10 μM; 2 hours) blocks PGE2-stimulated cell proliferation of HCA-7 cells.L-161982 (10 μM; 1 hour) blocks PGE2-stimulated ERK phosphorylation in HCA-7 cells.L-161982 induces apoptosis, cell cycle arrest, and inhibits prostaglandin E2-induced proliferation in oral squamous carcinoma Tca8113 cells. Cell Proliferation Assay Cell Line:HCA-7 cells Concentration:10 μM Incubation Time:2 hours Result:Blocked PGE2-induced cell proliferation.
  • In Vivo
    L-161982 (5?mg/kg; i.p.; once per day for 2 weeks) reduces arthritis lesions and lesion progression in CIA mice. Animal Model:Female DBA/1 mice of 6 to 8?weeks old (collagen-induced arthritis (CIA) mice model)Dosage:5?mg/kg Administration:i.p.; once per day for 2 weeks Result:Showed less joint swelling and lower arthritis score after 35?days post immunization.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Prostaglandin Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    147776-06-5
  • Formula Weight
    654.72
  • Molecular Formula
    C32H29F3N4O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (152.74 mM)
  • SMILES
    CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1sccc1C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Maljuri? N, et al. Quantitative structure -retention relationship modeling of selected antipsychotics and their impurities in green liquid chromatography using cyclodextrin mobile phases. Anal Bioanal Chem. 2018 Apr;410(10):2533-2550.
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