
AUTEN-67
CAS No. 1783800-77-0
AUTEN-67( Autophagy Enhancer 67 | AUTEN67 )
Catalog No. M12684 CAS No. 1783800-77-0
A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively.
Purity : >98% (HPLC)






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Biological Information
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Product NameAUTEN-67
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively.
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DescriptionA small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively; shows no activity for CDC25B , other phosphatase, PTPN1; significantly increases autophagic flux in cell lines and in vivo models, promotes longevity and protects neurons from undergoing stress-induced cell death; also restores nesting behavior in a murine model of Alzheimer disease, without apparent side effects.
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In Vitro——
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In VivoAnimal Model:Alzheimer disease model (Mice expressing the human APP)Dosage:19 mg/kg, 3 times a week for 3 month Administration:Oral administration Result:Restored nesting behavior by around 30%.Decreased Amyloid β levels in the hemibrain of mice.
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SynonymsAutophagy Enhancer 67 | AUTEN67
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number1783800-77-0
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Formula Weight474.45
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Molecular FormulaC23H14N4O6S
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Purity>98% (HPLC)
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Solubility——
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SMILESC1=CC=C2C(=C1)C(=O)C(=C(C2=O)N3C=NC4=CC=CC=C43)NS(=O)(=O)C5=CC=C(C=C5)[N+](=O)[O-]
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Chemical NameN-(3-(1H-benzo[d]imidazol-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-nitrobenzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Papp D, et al. Autophagy. 2016;12(2):273-86.
2. Billes V, et al. J Huntingtons Dis. 2016 May 7;5(2):133-47.
molnova catalog



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