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AUTEN-67

CAS No. 1783800-77-0

AUTEN-67( Autophagy Enhancer 67 | AUTEN67 )

Catalog No. M12684 CAS No. 1783800-77-0

A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AUTEN-67
  • Note
    Research use only, not for human use.
  • Brief Description
    A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively.
  • Description
    A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively; shows no activity for CDC25B , other phosphatase, PTPN1; significantly increases autophagic flux in cell lines and in vivo models, promotes longevity and protects neurons from undergoing stress-induced cell death; also restores nesting behavior in a murine model of Alzheimer disease, without apparent side effects.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Alzheimer disease model (Mice expressing the human APP)Dosage:19 mg/kg, 3 times a week for 3 month Administration:Oral administration Result:Restored nesting behavior by around 30%.Decreased Amyloid β levels in the hemibrain of mice.
  • Synonyms
    Autophagy Enhancer 67 | AUTEN67
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1783800-77-0
  • Formula Weight
    474.45
  • Molecular Formula
    C23H14N4O6S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC=C2C(=C1)C(=O)C(=C(C2=O)N3C=NC4=CC=CC=C43)NS(=O)(=O)C5=CC=C(C=C5)[N+](=O)[O-]
  • Chemical Name
    N-(3-(1H-benzo[d]imidazol-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-nitrobenzenesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Papp D, et al. Autophagy. 2016;12(2):273-86. 2. Billes V, et al. J Huntingtons Dis. 2016 May 7;5(2):133-47.
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