Orobol
CAS No. 480-23-9
Orobol ( 3'-Hydroxygenistein; 3’,4’,5,7-tetrahydroxy-isoflavon )
Catalog No. M29205 CAS No. 480-23-9
Orobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α/β/γ/K/δ. Orobol exhibits anti-skin-aging and anti-obesity effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 258 | Get Quote |
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100MG | Get Quote | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameOrobol
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NoteResearch use only, not for human use.
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Brief DescriptionOrobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α/β/γ/K/δ. Orobol exhibits anti-skin-aging and anti-obesity effects.
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DescriptionOrobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α/β/γ/K/δ. Orobol exhibits anti-skin-aging and anti-obesity effects.(In Vitro):Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK with IC50s of 1.24-4.45 μM. Orobol (5-20 μM) effectively suppresses MDI (isobutylmethylxanthine, dexamethasone, and insulin (MDI))-induced phosphorylation of 4E-BP1. Orobol binds to CK1ε in an ATP-competitive manner.(In Vivo):In C57BL/6J mice, Orobol (10?mg/kg; intragastrically) attenuates high-fat diet-induced weight gain (17.3%) and lipid accumulation without affecting food intake.
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Synonyms3'-Hydroxygenistein; 3’,4’,5,7-tetrahydroxy-isoflavon
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBCL
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Research Area——
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Indication——
Chemical Information
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CAS Number480-23-9
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Formula Weight286.2
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Molecular FormulaC15H10O6
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Purity>98% (HPLC)
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Solubility——
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SMILESOc1cc(O)c2c(c1)occ(-c1ccc(O)c(O)c1)c2=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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