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Home - Products - Chromatin/Epigenetic - COX - ASP-6537

ASP-6537

CAS No. 524699-72-7

ASP-6537 ( ASP6537;ASP6537;FK-881;FK 881;FR 122047 )

Catalog No. M14855 CAS No. 524699-72-7

ASP-6537 (ASP6537) is a novel potent, selective, reversible cyclooxygenase-1 (COX-1) inhibitor with IC50 of 4.9 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    ASP-6537
  • Note
    Research use only, not for human use.
  • Brief Description
    ASP-6537 (ASP6537) is a novel potent, selective, reversible cyclooxygenase-1 (COX-1) inhibitor with IC50 of 4.9 nM.
  • Description
    ASP-6537 (ASP6537) is a novel potent, selective, reversible cyclooxygenase-1 (COX-1) inhibitor with IC50 of 4.9 nM; displays 650-fold selectivity over COX-2 (IC50=3.2 uM); dose dependently inhibits carrageenan-induced paw edema (ED30=22 mg/kg) and paw swelling associated with adjuvant arthritis (ED50=17 mg/kg) in rats; also inhibits TXA2 production more selectively than aspirin in in vitro and in vivo, exerts potent antithrombotic effect in rats.
  • Synonyms
    ASP6537;ASP6537;FK-881;FK 881;FR 122047
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    COX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    524699-72-7
  • Formula Weight
    311.34
  • Molecular Formula
    C17H17N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COC1=CC=C(C2=NC(OC)=NN2C3=CC=C(OC)C=C3)C=C1
  • Chemical Name
    3-methoxy-1,5-bis(4-methoxyphenyl)-1H-1,2,4-triazole

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Imanishi J, et al. Biochem Pharmacol. 2011 Oct 1;82(7):746-54.
2. Sakata C, et al. Thromb Res. 2013 Jul;132(1):56-62.
3. Sakata C, et al. Eur J Pharmacol. 2017 Mar 5;798:72-76.
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