Cart
sales@molnova.com
Home - Products - Microbiology/Virology - Fungal - VT-1161

VT-1161

CAS No. 1340593-59-0

VT-1161( VT1161 )

Catalog No. M11365 CAS No. 1340593-59-0

VT-1161 is a potent, highly-selective, and oral fungal CYP51 inhibitor with Kd of ≤ 39 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 260 In Stock
10MG 410 In Stock
25MG 740 In Stock
50MG 1233 In Stock
100MG 1647 In Stock
200MG 2232 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    VT-1161
  • Note
    Research use only, not for human use.
  • Brief Description
    VT-1161 is a potent, highly-selective, and oral fungal CYP51 inhibitor with Kd of ≤ 39 nM.
  • Description
    VT-1161 is a potent, highly-selective, and oral fungal CYP51 inhibitor with Kd of ≤ 39 nM; demonstrates >2,000-fold selectivit over human CYP51, weakly inhibits human CYP2C9, CYP2C19, and CYP3A4; exhibits excellent potency against key yeast and dermatophyte strains.Fungal Infection Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    VT1161
  • Pathway
    Microbiology/Virology
  • Target
    Fungal
  • Recptor
    Fungal
  • Research Area
    Infection
  • Indication
    Fungal Infection

Chemical Information

  • CAS Number
    1340593-59-0
  • Formula Weight
    527.403
  • Molecular Formula
    C23H16F7N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (474.03 mM)
  • SMILES
    FC(F)(COC1=CC=C(C=C1)C2=CN=C(C=C2)C(F)(F)[C@@](O)(C3=CC=C(C=C3F)F)CN4N=NN=C4)F
  • Chemical Name
    (R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hoekstra WJ, et al. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3455-8. 2. Warrilow AG, et al. Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7. 3. Garvey EP, et al. Antimicrob Agents Chemother. 2015 Sep;59(9):5567-73.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Fosfluconazole

    A water-soluble, phosphate prodrug of fluconazole, a triazole antifungal agent and 14-alpha demethylase inhibitor used in the treatment and prevention of superficial and systemic fungal infections.

  • Itraconazole

    A triazole antifungal agent for fungal infections via inhibition of lanosterol 14α-demethylase.

  • Posaconazole

    A triazole antifungal agent that blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase and accumulation of methylated sterol precursors.

Sign In Join Free