Fosmanogepix

Research use only, not for human use.

Fosmanogepix (APX001 prodrug) is a novel antifungal agent.

Fosmanogepix (APX001 prodrug) is a novel antifungal agent, the prodrug form of APX001, which inhibits the fungal protein Gwt1.

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Animal Model:murine model of cryptococcal meningitis Dosage:390 mg/kg Administration:Oral gavage (p.o.)Result:Observed significant differences (P < 0.05) fungal burden and reduced the fungal burden compared to untreated control in the lung tissue.Reduced the fungal burden of 0.78 log10 CFU/g compared with control group in brain tissue.Animal Model:CD-1 mice Dosage:100 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Extended the half-life of the active moiety, APX001A, from 1.3 to 8.8 h, resulting in a 9-fold increase in the area under the curve (AUC).

APX001 prodrug | E1210 prodrug

Microbiology/Virology

Fungal

Fungal

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2091769-17-2

468.406

C22H21N4O6P

>98% (HPLC)

In Vitro:?DMSO : 5 mg/mL (10.67 mMult)

C1=CC=NC(=C1)OCC2=CC=C(C=C2)CC3=NOC(=C3)C4=C([N+](=CC=C4)COP(=O)(O)[O-])N

Pyridinium, 2-amino-1-[(phosphonooxy)methyl]-3-[3-[[4-[(2-pyridinyloxy)methyl]phenyl]methyl]-5-isoxazolyl]-, inner salt

(-20℃)

With Ice Pack

≥ 2 years