Pyr3
CAS No. 1160514-60-2
Pyr3 ( —— )
Catalog No. M26800 CAS No. 1160514-60-2
Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).
Purity : >98% (HPLC)
Size | Price / USD | Stock | Quantity |
2MG | 40 | Get Quote |
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5MG | 63 | Get Quote |
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10MG | 88 | Get Quote |
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25MG | 203 | Get Quote |
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50MG | 344 | Get Quote |
|
100MG | 484 | Get Quote |
|
200MG | 699 | Get Quote |
|
500MG | 1062 | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NamePyr3
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NoteResearch use only, not for human use.
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Brief DescriptionPyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).
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DescriptionPyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).(In Vitro):Pyr3 becomes apparent at 0.3 μM and is almost complete at 3 μM. Ca2+ influx is inhibited by Pyr3 in cells co-expressing TRPC3 plus TRPC6 but not in cells co-expressing TRPC1 plus TRPC5. The Ang II-induced NFAT translocation is suppressed by Pyr3 (IC50 = 0.05 μM), but weakly by Pyr2 (IC50 = 2 μM) in a concentration-dependent manner.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorLXRα; LXRβ
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Research Area——
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Indication——
Chemical Information
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CAS Number1160514-60-2
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Formula Weight456.6
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Molecular FormulaC16H11Cl3F3N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(OCC)C=1C=NN(C2=CC=C(C=C2)NC(=O)C(Cl)=C(Cl)Cl)C1C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Pyr10
Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells (IC50: 0.72 μM) (IC50 of 13.08 μM for store-operated Ca2+ entry in BRL-2H3 cells) .
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Pyr3
Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).
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Clemizole
An H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells.