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BDA-366

CAS No. 1909226-00-1

BDA-366( NSC-639366 | NSC639366 | BDA366 )

Catalog No. M12991 CAS No. 1909226-00-1

A potent, selective Bcl2 BH4 domain antagonist with Ki of 3.3 nM; shows no affinity for other Bcl2 family members, including Bcl-XL, Mcl-1, or Bfl-1/A1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 471 In Stock
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Biological Information

  • Product Name
    BDA-366
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective Bcl2 BH4 domain antagonist with Ki of 3.3 nM; shows no affinity for other Bcl2 family members, including Bcl-XL, Mcl-1, or Bfl-1/A1.
  • Description
    A potent, selective Bcl2 BH4 domain antagonist with Ki of 3.3 nM; shows no affinity for other Bcl2 family members, including Bcl-XL, Mcl-1, or Bfl-1/A1; induces apoptotic cell death in a Bax-dependent manner, and induces calcium (Ca2+) release via inhibition of Bcl2/IP3R interaction; potently represses lung cancer in vivo, and induces Bcl2 conformational change in tumor tissues.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NSC-639366 | NSC639366 | BDA366
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1909226-00-1
  • Formula Weight
    423.5
  • Molecular Formula
    C24H29N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCN(CC)CC(CNC1=C2C(=C(C=C1)NCC3CO3)C(=O)C4=CC=CC=C4C2=O)O
  • Chemical Name
    1-(((S)-3-(diethylamino)-2-hydroxypropyl)amino)-4-((((S)-oxiran-2-yl)methyl)amino)anthracene-9,10-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Han B, et al. Cancer Cell. 2015 Jun 8;27(6):852-63. 2. Deng J, et al. Oncotarget. 2016 May 10;7(19):27753-63. 3. Vervloessem T, et al. Aging (Albany NY). 2015 Oct;7(10):748-9.
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