AM966

CAS No. 1228690-19-4

AM966 ( AM-966; AM 966; AM966 )

Catalog No. M17206 CAS No. 1228690-19-4

AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 31 In Stock
5MG 50 In Stock
10MG 80 In Stock
25MG 147 In Stock
50MG 250 In Stock
100MG 402 In Stock
500MG 898 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    AM966
  • Note
    Research use only, not for human use.
  • Brief Description
    AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.
  • Description
    AM966 is a potent, selective and orally active LPA(1) receptor antagonist which inhibits lung fibrosis in the mouse bleomycin model.Last. In vitro, AM966 inhibited LPA-stimulated intracellular calcium release (IC(50)= 17 nM) from Chinese hamster ovary cells stably expressing human LPA(1) receptors and inhibited LPA-induced chemotaxis (IC(50)= 181 nM) of human IMR-90 lung fibroblasts expressing LPA(1) receptors. AM966 demonstrated a good pharmacokinetic profile following oral dosing in mice. In the mouse, AM966 reduced lung injury, vascular leakage, inflammation and fibrosis at multiple time points following intratracheal bleomycin instillation. AM966 also decreased lactate dehydrogenase activity and tissue inhibitor of metalloproteinase-1, transforming growth factor beta1, hyaluronan and matrix metalloproteinase-7, in bronchoalveolar lavage fluid.
  • Synonyms
    AM-966; AM 966; AM966
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    LPA1
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    1228690-19-4
  • Formula Weight
    490.94
  • Molecular Formula
    C27H23ClN2O5
  • Purity
    98%
  • Solubility
    DMSO : ≥ 105 mg/mL. 213.88 mM
  • SMILES
    O=C(O)CC(C=C1)=CC=C1C(C=C2)=CC=C2C3=C(NC(O[C@H](C)C4=C(Cl)C=CC=C4)=O)C(C)=NO3
  • Chemical Name
    (4'-(4-((R)-1-(2-Chlorophenyl)ethoxycarbonylamino)-3-methylisoxazol-5-yl)biphenyl-4-yl)acetic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Swaney, JS, et al. A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model. Br J Pharmacol. 2010 Aug;160(7):1699-713.
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