AM966
CAS No. 1228690-19-4
AM966 ( AM-966; AM 966; AM966 )
Catalog No. M17206 CAS No. 1228690-19-4
AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 31 | In Stock |
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5MG | 50 | In Stock |
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10MG | 80 | In Stock |
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25MG | 147 | In Stock |
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50MG | 250 | In Stock |
|
100MG | 402 | In Stock |
|
500MG | 898 | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameAM966
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NoteResearch use only, not for human use.
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Brief DescriptionAM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.
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DescriptionAM966 is a potent, selective and orally active LPA(1) receptor antagonist which inhibits lung fibrosis in the mouse bleomycin model.Last. In vitro, AM966 inhibited LPA-stimulated intracellular calcium release (IC(50)= 17 nM) from Chinese hamster ovary cells stably expressing human LPA(1) receptors and inhibited LPA-induced chemotaxis (IC(50)= 181 nM) of human IMR-90 lung fibroblasts expressing LPA(1) receptors. AM966 demonstrated a good pharmacokinetic profile following oral dosing in mice. In the mouse, AM966 reduced lung injury, vascular leakage, inflammation and fibrosis at multiple time points following intratracheal bleomycin instillation. AM966 also decreased lactate dehydrogenase activity and tissue inhibitor of metalloproteinase-1, transforming growth factor beta1, hyaluronan and matrix metalloproteinase-7, in bronchoalveolar lavage fluid.
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SynonymsAM-966; AM 966; AM966
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PathwayOthers
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TargetOther Targets
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RecptorLPA1
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1228690-19-4
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Formula Weight490.94
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Molecular FormulaC27H23ClN2O5
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Purity98%
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SolubilityDMSO : ≥ 105 mg/mL. 213.88 mM
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SMILESO=C(O)CC(C=C1)=CC=C1C(C=C2)=CC=C2C3=C(NC(O[C@H](C)C4=C(Cl)C=CC=C4)=O)C(C)=NO3
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Chemical Name(4'-(4-((R)-1-(2-Chlorophenyl)ethoxycarbonylamino)-3-methylisoxazol-5-yl)biphenyl-4-yl)acetic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Swaney, JS, et al. A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model. Br J Pharmacol. 2010 Aug;160(7):1699-713.
molnova catalog
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