Neobavaisoflavone

Research use only, not for human use.

Neobavaisoflavone is isolated as a DNA polymerase inhibitor.

Neobavaisoflavone is a natural isoflavone that was first isolated from seeds of P. corylifolia, which are used in traditional herbal medicine to treat various skin diseases. Neobavaisoflavone sensitizes apoptosis via the inhibition of metastasis in TRAIL-resistant human glioma U373MG cells.

Neobavaisoflavone (1-50 μM; 20 h) decreases NO (ED50=25 μM) and cytokine (ED50s=23.11, 5.03, 5.23, 5.26 and 18.80 μM for IL-1β, IL-6, IL-12p40, IL-12p70 and TNF-α, respectively) production in LPS plus IFN-γ-stimulated RAW264.7 macrophages.Neobavaisoflavone (1-100 μM; 30 min) decreases the chemiluminescence in PMA-stimulated RAW264.7 macrophages, with an ED50 of 19.94 μM in activated RAW264.7 cells.Neobavaisoflavone (1-100 μM); 20 h) has no effect on the viability and is not toxic to RAW264.7 cells.Neobavaisoflavone (20-50 μM; 48 h) inhibits prostate cancer cell proliferation by inducing cytotoxicity and apoptosis in a dose-dependent manner. Neobavaisoflavone (2-8 μM; 7 d) inhibitsRANKL‐mediated osteoclastogenesis in bone marrow monocytes (BMMCs) and RAW264.7 cells dose dependently at the early stage.

Neobavaisoflavone (30 mg/kg; i.p. for 6 weeks) inhibits osteoclastogenesis, promotes osteogenesis and ameliorates bone loss in ovariectomized mice. Animal Model:C57BL/6 female mice (8 weeksd; 20-25 g) were removed bilateral ovaries Dosage:30 mg/kg Administration:I.p. for 6 weeks Result:Attenuated bone loss by inhibiting osteoclast activation and promoting osteogenesis in ovariectomized mice.

Neobavaisoflavone

Others

Other Targets

DNA polymerase

Others-Field

——

41060-15-5

322.36

C20H18O4

>98% (HPLC)

DMSO : ≥ 31 mg/mL; 96.17 mM

CC(=CCC1=C(C=CC(=C1)C2=COC3=C(C2=O)C=CC(=C3)O)O)C

7-hydroxy-3-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-4H-1-benzopyran-4-one

(-20℃)

With Ice Pack

≥ 2 years