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AIM-100

CAS No. 873305-35-2

AIM-100( AIM 100 | AIM100 )

Catalog No. M16349 CAS No. 873305-35-2

AIM-100 (AIM100) is a highly potent inhibitor of Ack1 (TNK2) (IC50=24 nM), selective for Ack1 over ABL1, BTK, Lck and LYN.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AIM-100
  • Note
    Research use only, not for human use.
  • Brief Description
    AIM-100 (AIM100) is a highly potent inhibitor of Ack1 (TNK2) (IC50=24 nM), selective for Ack1 over ABL1, BTK, Lck and LYN.
  • Description
    AIM-100 (AIM100) is a highly potent inhibitor of Ack1 (TNK2) (IC50=24 nM), selective for Ack1 over ABL1, BTK, Lck and LYN; inhibits Ack1 Tyr284-phosphorylation attenuated pTyr267-AR transcriptional activity which in turn resulted in cell cycle arrest; inhibits pTyr284 -Ack1 expression, and prostate cancer cell proliferation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AIM 100 | AIM100
  • Pathway
    Tyrosine Kinase
  • Target
    Ack1 (TNK2)
  • Recptor
    Ack1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    873305-35-2
  • Formula Weight
    371.44
  • Molecular Formula
    C23H21N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C12=NC=NC(NC[C@H]3OCCC3)=C1C(C4=CC=CC=C4)=C(C5=CC=CC=C5)O2
  • Chemical Name
    Furo[2,3-d]pyrimidin-4-amine, 5,6-diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mahajan K, et al. Prostate. 2010 Sep 1;70(12):1274-85. 2. Mahajan K, et al. Am J Pathol. 2012 Apr;180(4):1386-93. 3. Mahajan K, et al. J Biol Chem. 2012 Jun 22;287(26):22112-22. 4. DiMauro EF, et al. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2305-9.
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