XMD16-5

Research use only, not for human use.

XMD16-5 is a potent Ack1 (TNK2) inhibitor with IC50 of 0.38 uM in ELISA assay.

XMD16-5 is a potent Ack1 (TNK2) inhibitor with IC50 of 0.38 uM in ELISA assay; exhibits potent inhibition of growth of the TNK2 mutant expressing cell lines with IC50s of 16 nM and 77 nM for the D163E and R806Q mutations.

XMD16-5 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD16-5 has IC50s of 16 nM and 77 nM for the D163E and R806Q mutations. The effects of XMD16-5 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD16-5.

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XMD16-5 | XMD-16-5 | XMD 16-5 | XMD165

Tyrosine Kinase

Ack1 (TNK2)

TNK2

Cancer

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1345098-78-3

416.47566

C23H24N6O2

>98% (HPLC)

DMSO: ≥ 29 mg/mL

OC(CC1)CCN1C(C=C2)=CC=C2NC3=NC=C4C(N(C)C(C=CC=C5)=C5C(N4)=O)=N3

6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-11-methyl-

(-20℃)

With Ice Pack

≥ 2 years