Crebinostat ( Crebinostat )

Catalog No. M10345 CAS No. 1092061-61-4

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Product Name

Crebinostat
Note

Research use only, not for human use.
Brief Description

Crebinostat is a novel cognitive enhancer that inhibits class I HDAC/1/2/3.
Description

Crebinostat is a novel cognitive enhancer that inhibits class I HDAC/1/2/3 (IC50=0.7/1.0/2.0 nM), class IIb HDAC6 (IC50=9.3 nM) with weaker inhibition of the class I HDAC8 and no significant inhibition of the class IIa HDAC/4/5/7/9; potently induces acetylation of both histone H3 and histone H4 as well as enhanced the expression of the CREB target gene Egr1 in cultured mouse primary neurons; upregulates Bdnf and Grn, and downregulates Mapt (tau) gene expression-genes; brain penetrant.
Synonyms

Crebinostat
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

——
Indication

——

CAS Number

1092061-61-4
Formula Weight

353.42
Molecular Formula

C20H23N3O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NO)CCCCCC(N/N=C/C1=CC=C(C2=CC=CC=C2)C=C1)=O
Chemical Name

Heptanoic acid,7-(hydroxyamino)-7-oxo-,2-([1,1'-biphenyl]-4-ylmethylene)hydrazide

1. Fass DM, et al. Neuropharmacology. 2013 Jan;64:81-96.
2. Ghosh B, et al. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1265-71.

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