ACBI1 ( —— )

Catalog No. M24091 CAS No. 2375564-55-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

ACBI1
Note

Research use only, not for human use.
Brief Description

ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively.
Description

ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.
Synonyms

——
Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis;Epigenetic Reader Domain;PROTAC
Research Area

——
Indication

——

CAS Number

2375564-55-7
Formula Weight

936.1
Molecular Formula

C49H58FN9O7S
Purity

>98% (HPLC)
Solubility

DMSO:100 mg/mL (106.83 mM)
SMILES

CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(C4(CC4)F)=O)=O)=O)C(OCCOC5=CC=C(CN6CCN(C7=CC(C8=C(O)C=CC=C8)=NN=C7N)CC6)C=C5)=C2
Chemical Name

——

1.Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.

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