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ACBI1

CAS No. 2375564-55-7

ACBI1( —— )

Catalog No. M24091 CAS No. 2375564-55-7

ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ACBI1
  • Note
    Research use only, not for human use.
  • Brief Description
    ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively.
  • Description
    ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.
  • In Vitro
    ACBI1 (1-10000 nM； 3-7 days) shows anti-proliferative activity.ACBI1 (0.3 μM; 100 h) induces apoptosis in SK-MEL-5 cells.ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase von Hippel-Lindau. Cell Proliferation Assay Cell Line:MV-4-11, NCI-H1568 cells Concentration:0-1000 nM Incubation Time:3-7 days Result:Showed anti-proliferative activity with IC50 of 29, 68 nM for MV-4-11, NCI-H1568 cells, respectively.Apoptosis Analysis Cell Line:SK-MEL-5 cells Concentration:0.3 μM Incubation Time:100 hResult:Induced apoptosis in SK-MEL-5 cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis|Epigenetic Reader Domain|PROTAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2375564-55-7
  • Formula Weight
    936.1
  • Molecular Formula
    C49H58FN9O7S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (106.83 mM)
  • SMILES
    CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(C4(CC4)F)=O)=O)=O)C(OCCOC5=CC=C(CN6CCN(C7=CC(C8=C(O)C=CC=C8)=NN=C7N)CC6)C=C5)=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.
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