ABX-1431 ( ABX1431;ABX 1431 )

Catalog No. M11904 CAS No. 1446817-84-0

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Datasheet

HNMR

HPLC

MSDS

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Product Name

ABX-1431
Note

Research use only, not for human use.
Brief Description

ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL).
Description

ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL); displays 23-fold selectivity for MGLL versus ABHD6 and CES1c, as well as exquisite selectivity of against other members of the serine hydrolase class; inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model.Pain Phase 1 Clinical
Synonyms

ABX1431;ABX 1431
Pathway

Metabolic Enzyme/Protease
Target

MAGL
Recptor

hMGLL;mMGLL
Research Area

Neurological Disease
Indication

Pain

CAS Number

1446817-84-0
Formula Weight

507.40
Molecular Formula

C20H22F9N3O2
Purity

>98% (HPLC)
Solubility

DMSO: 100 mg/mL, 197.08 mMWater: InsolubleEthanol: 10 mg/mL, 19.71 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C(N1CCN(CC2=CC=C(C(F)(F)F)C=C2N3CCCC3)CC1)OC(C(F)(F)F)C(F)(F)F
Chemical Name

1,1,1,3,3,3-hexafluoropropan-2-yl-4-[[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate

1. Cisar JS, et al. J Med Chem. 2018 Aug 1. doi: 10.1021/acs.jmedchem.8b00951.

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