Cart
sales@molnova.com
Home - Products - Apoptosis - NF-κB - ABD345

ABD345

CAS No. 1055896-51-9

ABD345( ABD-345 | ABD 345 )

Catalog No. M10255 CAS No. 1055896-51-9

ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    ABD345
  • Note
    Research use only, not for human use.
  • Brief Description
    ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation.
  • Description
    ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation; inhibits osteoclast formation in mouse bone marrow cultures (IC50=1.7 uM) without any effects on bone marrow macrophage viability; inhibits RANKL-induced phosphorylation of IκB and ERK in M-CSF-dependent bone marrow macrophage cultures; inhibits both RANKL- and TNF-induced NF-κB and MAPK signalling in osteoclasts and macrophages, and inflammation and bone destruction in mouse model of rheumatoid arthritis.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ABD-345 | ABD 345
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    NF-κB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1055896-51-9
  • Formula Weight
    318.364
  • Molecular Formula
    C19H20F2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    1-(2',4'-Difluoro-2-methyl[1,1'-biphenyl]-4-yl)-6-hydroxy-1-hexanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Coste E, et al. Ann Rheum Dis. 2015 Jan;74(1):220-6.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Edasalonexent

    Edasalonexent (CAT-1004) is a bifunctional, orally administered small molecule that covalently links 2 compounds known to inhibit NF‐κB, salicylic acid and docosahexaenoic acid (DHA).

  • 5-hydroxy-78-dimetho...

    5-hydroxy-78-dimethoxyflavone has anti-hypoxia activity it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-78-dimethoxyflavone significantly inhibits the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages.

  • SR12343

    SR12343 (SR-12343) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation.

Sign In Join Free