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ABD345

CAS No. 1055896-51-9

ABD345( ABD-345 | ABD 345 )

Catalog No. M10255 CAS No. 1055896-51-9

ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ABD345
  • Note
    Research use only, not for human use.
  • Brief Description
    ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation.
  • Description
    ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation; inhibits osteoclast formation in mouse bone marrow cultures (IC50=1.7 uM) without any effects on bone marrow macrophage viability; inhibits RANKL-induced phosphorylation of IκB and ERK in M-CSF-dependent bone marrow macrophage cultures; inhibits both RANKL- and TNF-induced NF-κB and MAPK signalling in osteoclasts and macrophages, and inflammation and bone destruction in mouse model of rheumatoid arthritis.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ABD-345 | ABD 345
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    NF-κB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1055896-51-9
  • Formula Weight
    318.364
  • Molecular Formula
    C19H20F2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    1-(2',4'-Difluoro-2-methyl[1,1'-biphenyl]-4-yl)-6-hydroxy-1-hexanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Coste E, et al. Ann Rheum Dis. 2015 Jan;74(1):220-6.
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