ABD345( ABD-345 | ABD 345 )

Catalog No. M10255 CAS No. 1055896-51-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ABD345
Note

Research use only, not for human use.
Brief Description

ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation.
Description

ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation; inhibits osteoclast formation in mouse bone marrow cultures (IC50=1.7 uM) without any effects on bone marrow macrophage viability; inhibits RANKL-induced phosphorylation of IκB and ERK in M-CSF-dependent bone marrow macrophage cultures; inhibits both RANKL- and TNF-induced NF-κB and MAPK signalling in osteoclasts and macrophages, and inflammation and bone destruction in mouse model of rheumatoid arthritis.
In Vitro

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In Vivo

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Synonyms

ABD-345 | ABD 345
Pathway

Apoptosis
Target

NF-κB
Recptor

NF-κB
Research Area

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Indication

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CAS Number

1055896-51-9
Formula Weight

318.364
Molecular Formula

C19H20F2O2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

1-(2',4'-Difluoro-2-methyl[1,1'-biphenyl]-4-yl)-6-hydroxy-1-hexanone

1. Coste E, et al. Ann Rheum Dis. 2015 Jan;74(1):220-6.

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