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ABD345
CAS No. 1055896-51-9
ABD345( ABD-345 | ABD 345 )
Catalog No. M10255 CAS No. 1055896-51-9
ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameABD345
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NoteResearch use only, not for human use.
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Brief DescriptionABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation.
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DescriptionABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation; inhibits osteoclast formation in mouse bone marrow cultures (IC50=1.7 uM) without any effects on bone marrow macrophage viability; inhibits RANKL-induced phosphorylation of IκB and ERK in M-CSF-dependent bone marrow macrophage cultures; inhibits both RANKL- and TNF-induced NF-κB and MAPK signalling in osteoclasts and macrophages, and inflammation and bone destruction in mouse model of rheumatoid arthritis.
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In Vitro——
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In Vivo——
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SynonymsABD-345 | ABD 345
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PathwayApoptosis
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TargetNF-κB
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RecptorNF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number1055896-51-9
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Formula Weight318.364
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Molecular FormulaC19H20F2O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name1-(2',4'-Difluoro-2-methyl[1,1'-biphenyl]-4-yl)-6-hydroxy-1-hexanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Coste E, et al. Ann Rheum Dis. 2015 Jan;74(1):220-6.
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