Amgen16( Amgen 16 )

Catalog No. M10736 CAS No. 1202761-92-9

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HPLC

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Product Name

Amgen16
Note

Research use only, not for human use.
Brief Description

Amgen 16 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM.
Description

Amgen 16 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NFkB activity is NIK-dependent; IKKβ inhibitor MLX and dexamethasone enhances cytotoxicity of NIK-inhibitors in MMCLs with NIK-dependent NFkB activation, blocks BAFF induced NFkB activation in myeloma cells combined with IKKβ inhibitors.
In Vitro

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In Vivo

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Synonyms

Amgen 16
Pathway

Apoptosis
Target

NF-κB
Recptor

NF-κB
Research Area

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Indication

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CAS Number

1202761-92-9
Formula Weight

354.838
Molecular Formula

C19H19ClN4O
Purity

>98% (HPLC)
Solubility

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SMILES

C1CCC(C1)(C#CC2=CC3=C(CCN3C4=NC(=NC=C4Cl)N)C=C2)O
Chemical Name

1-((1-(2-amino-5-chloropyrimidin-4-yl)indolin-6-yl)ethynyl)cyclopentan-1-ol

1. Demchenko YN, et al. Oncotarget. 2014 Jun 30;5(12):4554-66. 2. Henry KL, et al. Sci Signal. 2018 Jul 31;11(541). pii: eaam8216.

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