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Amgen16
CAS No. 1202761-92-9
Amgen16( Amgen 16 )
Catalog No. M10736 CAS No. 1202761-92-9
Amgen 16 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAmgen16
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NoteResearch use only, not for human use.
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Brief DescriptionAmgen 16 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM.
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DescriptionAmgen 16 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NFkB activity is NIK-dependent; IKKβ inhibitor MLX and dexamethasone enhances cytotoxicity of NIK-inhibitors in MMCLs with NIK-dependent NFkB activation, blocks BAFF induced NFkB activation in myeloma cells combined with IKKβ inhibitors.
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In Vitro——
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In Vivo——
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SynonymsAmgen 16
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PathwayApoptosis
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TargetNF-κB
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RecptorNF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number1202761-92-9
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Formula Weight354.838
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Molecular FormulaC19H19ClN4O
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CCC(C1)(C#CC2=CC3=C(CCN3C4=NC(=NC=C4Cl)N)C=C2)O
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Chemical Name1-((1-(2-amino-5-chloropyrimidin-4-yl)indolin-6-yl)ethynyl)cyclopentan-1-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Demchenko YN, et al. Oncotarget. 2014 Jun 30;5(12):4554-66.
2. Henry KL, et al. Sci Signal. 2018 Jul 31;11(541). pii: eaam8216.
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