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SEMBL

CAS No. 1443448-82-5

SEMBL( SEMBL )

Catalog No. M11881 CAS No. 1443448-82-5

SEMBL is a potent NF-κB inhibitor that inhibits DNA binding of NF-κB component p65.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SEMBL
  • Note
    Research use only, not for human use.
  • Brief Description
    SEMBL is a potent NF-κB inhibitor that inhibits DNA binding of NF-κB component p65.
  • Description
    SEMBL is a potent NF-κB inhibitor that inhibits DNA binding of NF-κB component p65; inhibits LPS-induced NF-κB activation, iNOS expression, and inflammatory cytokine secretions; also inhibits NF-κB and cellular invasion in ovarian carcinoma ES-2 cells; enhances stability in aqueous solution compared with (-)-DHMEQ.
  • In Vitro
    SEMBL inhibits MMP-2 expression and cellular metastatic activity in ovarian carcinoma cells.SEMBL inhibits the cell-free DNA binding of NF-κB in the ES-2 nuclear extract and inhibits the constitutively activated NF-κB activity in ovarian carcinoma cells.SEMBL inhibits cellular migration, invasion and MMP-2 expression in ovarian carcinoma cells at non-toxic concentrations.
  • In Vivo
    ——
  • Synonyms
    SEMBL
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    NF-κB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1443448-82-5
  • Formula Weight
    233.223
  • Molecular Formula
    C12H11NO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (428.78 mM)
  • SMILES
    C=C([C@H](NC(C1=CC=CC=C1O)=O)CO2)C2=O
  • Chemical Name
    (S)-2-hydroxy-N-(4-methylene-5-oxotetrahydrofuran-3-yl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sidthipong K, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):562-566.
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