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ABD328

CAS No. 1055896-19-9

ABD328( ABD-328 | ABD 328 )

Catalog No. M10254 CAS No. 1055896-19-9

ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

ABD328
Note

Research use only, not for human use.
Brief Description

ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo.
Description

ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo; inhibits TNF-induced activation of the NF-κB pathway, ERK, JNK and MAPKs in osteoclasts and macrophages, suppresses inflammatory arthritis, inhibits joint destruction and prevented systemic bone loss in mice model of rheumatoid arthritis.
In Vitro

——
In Vivo

——
Synonyms

ABD-328 | ABD 328
Pathway

Apoptosis
Target

NF-κB
Recptor

NF-κB
Research Area

——
Indication

——

Chemical Information

CAS Number

1055896-19-9
Formula Weight

337.24
Molecular Formula

C18H18Cl2O2
Purity

>98% (HPLC)
Solubility

——
SMILES

C1=CC(=CC=C1C2=C(C=C(C=C2)Cl)Cl)C(=O)CCCCCO
Chemical Name

1-(2',4'-dichloro-[1,1'-biphenyl]-4-yl)-6-hydroxyhexan-1-one

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Coste E, et al. Ann Rheum Dis. 2015 Jan;74(1):220-6. 2. Idris AI, et al. Calcif Tissue Int. 2010 Dec;87(6):525-32.

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