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ABD328
CAS No. 1055896-19-9
ABD328( ABD-328 | ABD 328 )
Catalog No. M10254 CAS No. 1055896-19-9
ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameABD328
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NoteResearch use only, not for human use.
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Brief DescriptionABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo.
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DescriptionABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo; inhibits TNF-induced activation of the NF-κB pathway, ERK, JNK and MAPKs in osteoclasts and macrophages, suppresses inflammatory arthritis, inhibits joint destruction and prevented systemic bone loss in mice model of rheumatoid arthritis.
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In Vitro——
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In Vivo——
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SynonymsABD-328 | ABD 328
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PathwayApoptosis
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TargetNF-κB
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RecptorNF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number1055896-19-9
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Formula Weight337.24
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Molecular FormulaC18H18Cl2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC1=CC(=CC=C1C2=C(C=C(C=C2)Cl)Cl)C(=O)CCCCCO
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Chemical Name1-(2',4'-dichloro-[1,1'-biphenyl]-4-yl)-6-hydroxyhexan-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Coste E, et al. Ann Rheum Dis. 2015 Jan;74(1):220-6.
2. Idris AI, et al. Calcif Tissue Int. 2010 Dec;87(6):525-32.
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