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Home - Products - Nuclear Receptor/Transcription Factor - eIF - A-484954

A-484954

CAS No. 142557-61-7

A-484954( A484954 | A 484954 )

Catalog No. M11796 CAS No. 142557-61-7

A-484954 (A484954)?is a highly selective, small molecule eEF2K inhibitor with IC50 of 0.28 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    A-484954
  • Note
    Research use only, not for human use.
  • Brief Description
    A-484954 (A484954)?is a highly selective, small molecule eEF2K inhibitor with IC50 of 0.28 uM.
  • Description
    A-484954 (A484954)?is a highly selective, small molecule eEF2K inhibitor with IC50 of 0.28 uM; inhibits eEF2K and reduces eEF2 phosphorylation with little effect on cancer cell growth; inhibits MCT-induced PA hypertrophy and fibrosis in rats, inhibits MCT-induced NOX1 expression, ROS generation and MMP-2 activation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    A484954 | A 484954
  • Pathway
    Nuclear Receptor/Transcription Factor
  • Target
    eIF
  • Recptor
    eIF
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    142557-61-7
  • Formula Weight
    289.29
  • Molecular Formula
    C13H15N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 20 mg/mL69.13 mM;H2O : < 0.1 mg/mL
  • SMILES
    CCN1C(=O)C2=CC(=C(N=C2N(C1=O)C3CC3)N)C(=O)N
  • Chemical Name
    7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chen Z, et al. J Biol Chem. 2011 Dec 23;286(51):43951-8. 2. Edupuganti R, et al. Bioorg Med Chem. 2014 Sep 1;22(17):4910-6. 3. Kameshima S, et al. Am J Physiol Heart Circ Physiol. 2015 May 15;308(10):H1298-305.
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