Cart
sales@molnova.com
Home - Products - Nuclear Receptor/Transcription Factor - eIF - 4EGI-1

4EGI-1

CAS No. 315706-13-9

4EGI-1( eIF4E/eIF4G Interaction Inhibitor )

Catalog No. M14029 CAS No. 315706-13-9

4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 45 In Stock
5MG 81 In Stock
10MG 105 In Stock
25MG 208 In Stock
50MG 332 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    4EGI-1
  • Note
    Research use only, not for human use.
  • Brief Description
    4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E).
  • Description
    4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E); disrupts eIF4E/eIF4G association and inhibits cap-dependent translation; inhibits cellular expression of oncogenic proteins encoded by weak mRNAs, exhibits activity against multiple cancer cell lines.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    eIF4E/eIF4G Interaction Inhibitor
  • Pathway
    Nuclear Receptor/Transcription Factor
  • Target
    eIF
  • Recptor
    eIF-4E/eIF-4G
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    315706-13-9
  • Formula Weight
    451.2833
  • Molecular Formula
    C18H12Cl2N4O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 35 mg/mL
  • SMILES
    O=C(O)/C(CC1=CC=CC=C1[N+]([O-])=O)=N/NC2=NC(C3=CC=C(Cl)C(Cl)=C3)=CS2
  • Chemical Name
    Benzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Moerke NJ, et al. Cell. 2007 Jan 26;128(2):257-67. 2. Wang W, et al. Oncotarget. 2016 Apr 19;7(16):21728-41. 3. Papadopoulos E, et al. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3187-95.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • eIF4A3-IN-1q

    A potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM.

  • 2BAct

    2BAct (eIF2B activator 2BAct) is a novel, highly selective, CNS-permeable small molecule eIF2B activator with EC50 of 33 nM in cell-based reporter assays.

  • Pateamine A

    Pateamine A (Pateamine)?is a potent small molecule inhibitor of eukaryotic translation that stimulates eIF4AI/II and eIF4AIII activity.

Sign In Join Free