A-196

Research use only, not for human use.

A potent, selective and substrate-competitive inhibitor of protein lysine methyltransferases (PKMTs) SUV420H1 and SUV420H2 with IC50 of 25 nM and 144 nM, respectively.

A potent, selective and substrate-competitive inhibitor of protein lysine methyltransferases (PKMTs) SUV420H1 and SUV420H2 with IC50 of 25 nM and 144 nM, respectively; shows no activity for other PKMTs including PR-SET7, and PRMTs, DNMTases; induces a global decrease in H4K20me2 and H4K20me3 (EC50= 262 and 370 nM, respectively) and a concomitant increase in H4K20me1 (EC50=735 nM) in U2OS cells, inhibits 53BP1 foci formation upon ionizing radiation and reduces NHEJ-mediated DNA-break repair but does not affect homology-directed repair.

A196;A 196

Chromatin/Epigenetic

HMTase

HMTase

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359.25

C18H16Cl2N4

>98% (HPLC)

DMSO: ≥ 31 mg/mL

ClC1=C(Cl)C=C(C(C2=CC=NC=C2)=NN=C3NC4CCCC4)C3=C1

6,7-dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine

(-20℃)

With Ice Pack

≥ 2 years