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A-196
CAS No. 1982372-88-2
A-196( SGC A-196 | SGC A 196 | SGC A196 )
Catalog No. M17412 CAS No. 1982372-88-2
A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | In Stock |
|
| 5MG | 65 | In Stock |
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| 10MG | 87 | In Stock |
|
| 25MG | 176 | In Stock |
|
| 50MG | 329 | In Stock |
|
| 100MG | 498 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameA-196
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NoteResearch use only, not for human use.
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Brief DescriptionA-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively.
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DescriptionSGC A-196 is a potent inhibitor of SUV420H1 (IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM), a closely related pair of proteins which catalyze the di- and tri-methylation of H4K20.
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In VitroWestern Blot Analysis Cell Line:U2OS cells Concentration:0 μM, 0.075 μM, 0.15 μM, 0.3 μM, 0.6 μM, 1.25 μM, 2.5 μM, 5 μM Incubation Time:48 hours Result:Increased in H4K20me1 and decreased in both H4K20me2 and H4K20me3.
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In Vivo——
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SynonymsSGC A-196 | SGC A 196 | SGC A196
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PathwayOthers
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TargetOther Targets
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RecptorSUV420H1|SUV420H2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1982372-88-2
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Formula Weight359.25
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Molecular FormulaC18H16Cl2N4
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 31 mg/mL; 86.29 mM
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SMILESClc1cc3c(cc1Cl)c(nnc3NC2CCCC2)c4ccncc4
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Chemical NameCyclopentyl-(6,7-dichloro-4-pyridin-4-yl-phthalazin-1-yl)-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bromberg KD,etal.The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.Nat Chem Biol. 2017 Mar;13(3):317-324.
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