CYD-2-11 ( CYD-2-11; CYD 2 11; CYD211 )

Catalog No. M11797 CAS No. 1425944-22-4

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Product Name

CYD-2-11
Note

Research use only, not for human use.
Brief Description

CYD-2-11 is a novel potent, selective Bax agonist that targets the structural pocket proximal to S184 in the C-terminal region of Bax (Ki=34.1 nM).
Description

CYD-2-11 is a novel potent, selective Bax agonist that targets the structural pocket proximal to S184 in the C-terminal region of Bax (Ki=34.1 nM); shows no affinity for other Bcl-2 family members; directly activates Bax proapoptotic activity by inducing a conformational change enabling formation of Bax homooligomers in mitochondrial membranes; suppresses malignant growth without evident significant toxicity to normal tissues in mutant KRAS-driven lung cancer models; displays strong synergistic activity and overcomes rapalog resistance combined with RAD001.
Synonyms

CYD-2-11; CYD 2 11; CYD211
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

——
Indication

——

CAS Number

1425944-22-4
Formula Weight

358.40
Molecular Formula

C22H18N2O3
Purity

>98% (HPLC)
Solubility

——
SMILES

NCCOC1=CC=CC=C1/C=C2C3=C(C4=C/2C=CC=C4)C=CC([N+]([O-])=O)=C3
Chemical Name

(E)-2-(2-((2-nitro-9H-fluoren-9-ylidene)methyl)phenoxy)ethan-1-amine

1. Li R, et al. Cancer Res. 2017 Jun 1;77(11):3001-3012.

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