AG-14361

CAS No. 328543-09-5

AG-14361( AG14361 | AG-14361 | AG 14361. )

Catalog No. M14073 CAS No. 328543-09-5

AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 59 In Stock
5MG 128 In Stock
10MG 233 In Stock
25MG 453 In Stock
50MG 660 In Stock
100MG 888 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    AG-14361
  • Note
    Research use only, not for human use.
  • Brief Description
    AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides.
  • Description
    AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AG14361 | AG-14361 | AG 14361.
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    328543-09-5
  • Formula Weight
    320.39
  • Molecular Formula
    C19H20N4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 12 mg/mL (37.45 mM)
  • SMILES
    O=C1C2=C3C(N=C(C4=CC=C(CN(C)C)C=C4)N3CCN1)=CC=C2
  • Chemical Name
    1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one.

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Calabrese CR, et al. J Natl Y Inst, 2004, 96(1), 56-67.
molnova catalog
related products
  • Rucaparib Camsylate

    Rucaparib Camsylate is a PARP inhibitor (PARP1,Ki of 1.4 nM). Rucaparib Camsylate also displays binding affinity to eight other PARP domains. Rucaparib is the most effective PARP inhibitor in enzyme assays (Ki: 1.4 nM). Rucaparib inhibits PARP-1 activity by 97.1% at a concentration of 1 μM in permeabilized D283Med cells.

  • Fluzoparib

    fluzoparib is a novel, potent, and orally available inhibitor of PARP, potentially for the treatment of solid tumours.Fluzoparib potently inhibited PARP1 enzyme activity and induced DNA double-strand breaks, G2 /M arrest, and apoptosis in homologous recombination repair (HR)-deficient cells.?

  • Rucaparib phosphate

    An inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay.