5-Fluorouridine
CAS No. 316-46-1
5-Fluorouridine( —— )
Catalog No. M14032 CAS No. 316-46-1
5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
100MG | 35 | In Stock |
|
200MG | 50 | In Stock |
|
500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product Name5-Fluorouridine
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NoteResearch use only, not for human use.
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Brief Description5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid.
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Description5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compounds comprising a pyrimidine base attached to a sugar. 5-fluorouridine is known to target uridine phosphorylase. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.
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In Vitro5-Fluorouridine (167 μM; 24-96 h) inhibits MKN45 cells and MKN28 cells in a time-dependent manner.?5-Fluorouridine (10 μM; 24 h; HCT-116 cells) induces apoptosis and increases the percentage of apoptotic cells. 5-Fluorouridine upregulates the expression of 33 genes, including a group of genes as growth factors, cytokines and chemokines (e.g. IL-3, IL -4, B-cell growth factor 1 and stem cell growth factor).?5-Fluorouridine (10 μM; 8-24 h; HCT-116 cells) incorporates into both total and poly A RNA.
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In Vivo5-Fluorouridine (567-1500 mg/kg; i.p.; daily, for 20 d) induce gastrointestinal toxicity in the mice. Animal Model:Male CBA/J mice (17-20 g; 6-8 weeks of age)Dosage:Intraperitoneal injection; daily, 20 days Administration:567, 700, 900, 1100, 1300, and 1500 mg/kg Result:567, 700, 900, 1100, 1300, and 1500 mg/kg
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA synthesis| Upp
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Research Area——
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Indication——
Chemical Information
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CAS Number316-46-1
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Formula Weight262.19
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Molecular FormulaC9H11FN2O6
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Purity>98% (HPLC)
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SolubilityLimited solubility
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SMILESC1=C(C(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Spenkuch F, et al. Nucleic Acids Res. 2014 Nov 10;42(20):12735-45.
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