5-Fluorouridine

CAS No. 316-46-1

5-Fluorouridine( —— )

Catalog No. M14032 CAS No. 316-46-1

5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    5-Fluorouridine
  • Note
    Research use only, not for human use.
  • Brief Description
    5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid.
  • Description
    5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compounds comprising a pyrimidine base attached to a sugar. 5-fluorouridine is known to target uridine phosphorylase. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.
  • In Vitro
    5-Fluorouridine (167 μM; 24-96 h) inhibits MKN45 cells and MKN28 cells in a time-dependent manner.?5-Fluorouridine (10 μM; 24 h; HCT-116 cells) induces apoptosis and increases the percentage of apoptotic cells. 5-Fluorouridine upregulates the expression of 33 genes, including a group of genes as growth factors, cytokines and chemokines (e.g. IL-3, IL -4, B-cell growth factor 1 and stem cell growth factor).?5-Fluorouridine (10 μM; 8-24 h; HCT-116 cells) incorporates into both total and poly A RNA.
  • In Vivo
    5-Fluorouridine (567-1500 mg/kg; i.p.; daily, for 20 d) induce gastrointestinal toxicity in the mice. Animal Model:Male CBA/J mice (17-20 g; 6-8 weeks of age)Dosage:Intraperitoneal injection; daily, 20 days Administration:567, 700, 900, 1100, 1300, and 1500 mg/kg Result:567, 700, 900, 1100, 1300, and 1500 mg/kg
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA synthesis| Upp
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    316-46-1
  • Formula Weight
    262.19
  • Molecular Formula
    C9H11FN2O6
  • Purity
    >98% (HPLC)
  • Solubility
    Limited solubility
  • SMILES
    C1=C(C(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Spenkuch F, et al. Nucleic Acids Res. 2014 Nov 10;42(20):12735-45.
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