5-Fluorouridine

Research use only, not for human use.

5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid.

5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compounds comprising a pyrimidine base attached to a sugar. 5-fluorouridine is known to target uridine phosphorylase. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.

5-Fluorouridine (167 μM; 24-96 h) inhibits MKN45 cells and MKN28 cells in a time-dependent manner.?5-Fluorouridine (10 μM; 24 h; HCT-116 cells) induces apoptosis and increases the percentage of apoptotic cells. 5-Fluorouridine upregulates the expression of 33 genes, including a group of genes as growth factors, cytokines and chemokines (e.g. IL-3, IL -4, B-cell growth factor 1 and stem cell growth factor).?5-Fluorouridine (10 μM; 8-24 h; HCT-116 cells) incorporates into both total and poly A RNA.

5-Fluorouridine (567-1500 mg/kg; i.p.; daily, for 20 d) induce gastrointestinal toxicity in the mice. Animal Model:Male CBA/J mice (17-20 g; 6-8 weeks of age)Dosage:Intraperitoneal injection; daily, 20 days Administration:567, 700, 900, 1100, 1300, and 1500 mg/kg Result:567, 700, 900, 1100, 1300, and 1500 mg/kg

——

Cell Cycle/DNA Damage

DNA/RNA Synthesis

DNA synthesis| Upp

——

——

316-46-1

262.19

C9H11FN2O6

>98% (HPLC)

Limited solubility

C1=C(C(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)F

——

(-20℃)

With Ice Pack

≥ 2 years