Juglone

CAS No. 481-39-0

Juglone ( Regianin;5-Hydroxy-14-naphthoquinone )

Catalog No. M19883 CAS No. 481-39-0

Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family including human Pin1 yeast Ess1/Ptf1 and E. coli parvulin (Ki = 55.9 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 37 In Stock
10MG 50 In Stock
25MG 86 In Stock
50MG 122 In Stock
100MG 170 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Juglone
  • Note
    Research use only not for human use.
  • Brief Description
    Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family including human Pin1 yeast Ess1/Ptf1 and E. coli parvulin (Ki = 55.9 nM).
  • Description
    Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family including human Pin1 yeast Ess1/Ptf1 and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I II and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction both through Pin1-independent mechanisms.
  • Synonyms
    Regianin;5-Hydroxy-14-naphthoquinone
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    RNA polymerase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    481-39-0
  • Formula Weight
    174.15
  • Molecular Formula
    C10H6O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 15 mg/mL;Ethanol: 15 mg/mL
  • SMILES
    Oc1cccc2C(=O)C=CC(=O)c12
  • Chemical Name
    5-hydroxynaphthalene-14-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hennig L et al. Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone. Biochemistry. 1998 Apr 28;37(17):5953-60.
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