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Juglone
CAS No. 481-39-0
Juglone ( Regianin;5-Hydroxy-14-naphthoquinone )
Catalog No. M19883 CAS No. 481-39-0
Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family including human Pin1 yeast Ess1/Ptf1 and E. coli parvulin (Ki = 55.9 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 37 | In Stock |
|
| 10MG | 50 | In Stock |
|
| 25MG | 86 | In Stock |
|
| 50MG | 122 | In Stock |
|
| 100MG | 170 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJuglone
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NoteResearch use only not for human use.
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Brief DescriptionJuglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family including human Pin1 yeast Ess1/Ptf1 and E. coli parvulin (Ki = 55.9 nM).
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DescriptionJuglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family including human Pin1 yeast Ess1/Ptf1 and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I II and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction both through Pin1-independent mechanisms.
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SynonymsRegianin;5-Hydroxy-14-naphthoquinone
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorRNA polymerase
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Research Area——
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Indication——
Chemical Information
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CAS Number481-39-0
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Formula Weight174.15
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Molecular FormulaC10H6O3
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Purity>98% (HPLC)
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SolubilityDMSO: 15 mg/mL;Ethanol: 15 mg/mL
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SMILESOc1cccc2C(=O)C=CC(=O)c12
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Chemical Name5-hydroxynaphthalene-14-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hennig L et al. Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone. Biochemistry. 1998 Apr 28;37(17):5953-60.
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