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Home - Products - Metabolic Enzyme/Protease - Transferase - 3,5-Dinitrocatechol

3,5-Dinitrocatechol

CAS No. 7659-29-2

3,5-Dinitrocatechol( OR-486 | 3,5-Dinitropyrocatechol )

Catalog No. M27677 CAS No. 7659-29-2

OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    3,5-Dinitrocatechol
  • Note
    Research use only, not for human use.
  • Brief Description
    OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex.
  • Description
    OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex.(In Vitro):OR-486 is highly effective (IC50 = 12 nM) and selective in inhibiting COMT activity in vitro.(In Vivo):In mouse trachea (β1-AR dominant), significant suppression of ISO-induced relaxation was observed with the addition of OR-486. In GP trachea, in the presence of clorgiline plus OR-486, both normetadrenaline (NMA) and metadrenaline (MA) (10-4 M) significantly suppressed ISO-induced relaxation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    OR-486 | 3,5-Dinitropyrocatechol
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Transferase
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    7659-29-2
  • Formula Weight
    200.106
  • Molecular Formula
    C6H4N2O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Oc1cc(cc(c1O)[N+]([O-])=O)[N+]([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Plachká K, et al. Development, validation and comparison of UHPSFC and UHPLC methods for the determination of agomelatine and its impurities. J Pharm Biomed Anal. 2016 Jun 5;125:376-84.
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