1-Dodecylimidazole
CAS No. 4303-67-7
1-Dodecylimidazole ( N-Dodecylimidazole )
Catalog No. M28150 CAS No. 4303-67-7
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
200MG | 50 | In Stock |
|
500MG | 67 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product Name1-Dodecylimidazole
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NoteResearch use only, not for human use.
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Brief Description1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm.
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Description1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity.(In Vitro):N-dodecylimidazole, an acid activated detergent with a pKa of 6.3, has been shown to be cytotoxic to cells in culture. N-dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose dependent and was 100-fold greater at pHe 6.0 than pHe 7.0.(In Vivo):The hypocholesterolaemic activity of 1-dodecylimidazole results in part from the inhibition of cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase.1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) has lower serum cholesterol concentrations than control rats.
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SynonymsN-Dodecylimidazole
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorDrug Metabolite
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Research Area——
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Indication——
Chemical Information
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CAS Number4303-67-7
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Formula Weight236.4
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Molecular FormulaC15H28N2
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCCCCCCCCCCn1ccnc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Arnel Stockis, et al. Identification of mebeverine acid as the main circulating metabolite of mebeverine in man. J Pharm Biomed Anal. 2002 Jun 20;29(1-2):335-40.
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