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(S,R,S)-AHPC-PEG3-N3
CAS No. 1797406-80-4
(S,R,S)-AHPC-PEG3-N3 ( VH032-PEG3-N3 )
Catalog No. M22360 CAS No. 1797406-80-4
(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is extracted from patent WO/2016/146985A1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 33 | In Stock |
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| 5MG | 51 | In Stock |
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| 10MG | 80 | In Stock |
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| 25MG | 138 | In Stock |
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| 50MG | 177 | In Stock |
|
| 100MG | 260 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name(S,R,S)-AHPC-PEG3-N3
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NoteResearch use only, not for human use.
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Brief Description(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is extracted from patent WO/2016/146985A1.
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Description(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is extracted from patent WO/2016/146985A1. PROTAC has been developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compond via a suitable linker.
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SynonymsVH032-PEG3-N3
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PathwayPROTACs
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TargetPROTAC
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RecptorVHL
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Research Area——
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Indication——
Chemical Information
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CAS Number1797406-80-4
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Formula Weight645.77
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Molecular FormulaC30H43N7O7S
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Purity>98% (HPLC)
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SolubilityDMSO:50 mg/mL (77.43 mM; Need ultrasonic)
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SMILESO=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCN=[N+]=[N-]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. CIULLI, Alessio, et al. DERIVATIVES OF 1-[(CYCLOPENTYL OR 2-PYRROLIDINYL)CARBONYLAMINOMETHYL]-4-(1,3-THIAZOL-5-YL) BENZENE WHICH ARE USEFUL FOR THE TREATMENT OF PROLIFERATIVE, AUTOIMMUNE OR INFLAMMATORY DISEASES. WO2016146985A1.
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