5-Ethynyl-2-deoxyuridine

CAS No. 61135-33-9

5-Ethynyl-2-deoxyuridine( —— )

Catalog No. M33539 CAS No. 61135-33-9

5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    5-Ethynyl-2-deoxyuridine
  • Note
    Research use only, not for human use.
  • Brief Description
    5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.
  • Description
    5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. 5-Ethynyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Two month old female miceDosage:10, 20, 50, 100 or 200 mg/kg Administration:Single injection; intraperitoneally; 4 hours after EdU injection, brains were processed for EdU staining.Result:EdU positive cell numbers slightly increased in a dose-dependent manner both in control and running mice.
  • Synonyms
    ——
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    PROTAC Linker
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    61135-33-9
  • Formula Weight
    252.22
  • Molecular Formula
    C11H12N2O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (198.24 mM; Ultrasonic )H2O : 25 mg/mL (99.12 mM; Ultrasonic)
  • SMILES
    OC[C@H]1O[C@H](C[C@@H]1O)n1cc(C#C)c(=O)[nH]c1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chenbo Zeng, et al. Evaluation of 5-ethynyl-2'-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system. Brain Res. 2010 Mar 10;1319:21-32.?
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