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(R)-(-)-Ibuprofen

CAS No. 51146-57-7

(R)-(-)-Ibuprofen( R)-Ibuprofen )

Catalog No. M14765 CAS No. 51146-57-7

An enantiomer of Ibuprofen that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    (R)-(-)-Ibuprofen
  • Note
    Research use only, not for human use.
  • Brief Description
    An enantiomer of Ibuprofen that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids.
  • Description
    An enantiomer of Ibuprofen that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids; inhibits NF-κB activation (IC50=121.8 uM) in response to T-cell stimulation as well as block superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 =40-100 uM).Pain Approved.
  • In Vitro
    (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, with no inhibitory effect on COX, but is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids. (R)-(-)-Ibuprofen (1 μM) significantly reduces NF-κB activation and completely prevents NF-κB induction at 10 μM. (R)-(-)-Ibuprofen inhibits NF-κB luciferase activity with an IC50 of 121.8 μM, weaker than that of S(+)-ibuprofen (IC50, 61.7 μM). Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF.
  • In Vivo
    ——
  • Synonyms
    R)-Ibuprofen
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    NF-κB
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    51146-57-7
  • Formula Weight
    206.2808
  • Molecular Formula
    C13H18O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(O)[C@H](C)C1=CC=C(CC(C)C)C=C1
  • Chemical Name
    Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-,(αR)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Scheuren N, et al. Br J Pharmacol. 1998 Feb;123(4):645-52. 2. Evans AM. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. 3. Villanueva M, et al. Br J Clin Pharmacol. 1993 Mar;35(3):235-42.
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