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SR12343

CAS No. 2055101-86-3

SR12343( SR 12343 | SR-12343 )

Catalog No. M13191 CAS No. 2055101-86-3

SR12343 (SR-12343) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SR12343
  • Note
    Research use only, not for human use.
  • Brief Description
    SR12343 (SR-12343) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation.
  • Description
    SR12343 (SR-12343) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation, inhibits TNF-α-mediated NF-κB activation with IC50 of 11.34 uM in luciferase assays; inhibits lipopolysaccharide (LPS)-induced NF-κB activation by blocking the interaction between IKKβ and NEMO, significantly inhibits COX-2, IL-6, and iNOS expression at 50 uM in cellular assays; suppresses LPS-induced acute pulmonary inflammation, alleviates necrosis and muscle degeneration in mdx mice without overt liver toxicity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SR 12343 | SR-12343
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    NF-κB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2055101-86-3
  • Formula Weight
    368.659
  • Molecular Formula
    C15H15BrClN3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC(=CC(=C1)Br)CCNC(=O)CNC2=NC=C(C=C2)Cl
  • Chemical Name
    N-(3-bromophenethyl)-2-((5-chloropyridin-2-yl)amino)acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhao J, et al. PLoS Biol. 2018 Jun 11;16(6):e2004663.
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