Migraine is a chronic neurological disorder characterized by attacks of moderate or severe headache and reversible neurological and systemic symptoms. The most characteristic symptoms associated with migraine include photophobia, phonophobia, cutaneous allodynia,and gastrointestinal symptoms such as nausea and emesis.Understanding the biology of migraine through careful bench-based research has led to major classes of therapeutics being identified: triptans, serotonin 5-HT1B/1D receptor agonists; gepants, calcitonin gene-related peptide (CGRP) receptor antagonists; ditans, 5-HT1F receptor agonists, CGRP mechanisms monoclonal antibodies; and glurants, mGlu5 modulators; with the promise of more to come.

References

1.Peter J. Goadsby,et al. Physiol Rev 97: 553–622, 2017.