Parkinson's disease (PD) is the most common neurodegenerative movement disorder which results from the relentless degeneration of midbrain dopaminergic neurons. Parkinson’s disease (PD) affects 1% of the retirement-age population.It is characterized by the progressive degeneration of dopaminergic (DA) neurons in the substantia nigra, which disrupts motor control causing symptoms such as resting tremor, bradykinesia, and postural instability.The genetic and cellular analysis of these models is beginning to reveal fundamental insights into the pathogenic mechanisms. Numerous pathways and processes are disrupted in these models but some common themes are emerging. These often implicate aberrant synaptic function, protein aggregation, autophagy, oxidative stress, and mitochondrial dysfunction.

References

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