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Aromatase
Aromatase is the sole member of family 19 of the P450 superfamily of enzymes, termed CYP19. Aromatase is a microsomal protein that is found throughout the vertebrate phylum, but the human gene is unique compared with the rest of its superfamily.The aromatase reaction employs 3 moles of oxygen and 3 moles of NADPH for every mole of steroid substrate metabolized. Aromatase shares a number of structural features common to all cytochrome P450 species.Aromatase is most widely known for its roles in reproduction and reproductive system diseases, and as a target for inhibitor therapy in estrogen-sensitive diseases including cancer, endometriosis, and leiomyoma.
References
1.Blakemore J,et al. Physiology (Bethesda). 2016 Jul;31(4):258-69
References
1.Blakemore J,et al. Physiology (Bethesda). 2016 Jul;31(4):258-69
Endocrinology/Hormones
Aromatase
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Minamestane
catalog no : M36378
cas no: 105051-87-4
Minamestane is a novel irreversible aromatase inhibitor.Minamestane induces time-dependent inhibition of human placental aromatase with a half-life of 4 minutes and a K of 59 nM.Minamestane has antitumor activity.
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Finrozole
catalog no : M34254
cas no: 160146-17-8
Finrozole (MPV 2213ad) is a novel selective aromatase inhibitor that is partially reversible for breast development.
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Testolactone
catalog no : M22381
cas no: 968-93-4
Testolactone is an aromatase inhibitor, blocks conversion of androgens to estrogens.It is progesterone derivative with antineoplastic activity.?
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Geraniin
catalog no : M18888
cas no: 60976-49-0
Geraniin has a protective effect against OVX-induced rat osteoporosis.Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo.
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Flavokawain A
catalog no : M18443
cas no: 3420-72-2
Flavokawain A has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma.