Home - Products - Endocrinology/Hormones - Aromatase

Aromatase

Aromatase is the sole member of family 19 of the P450 superfamily of enzymes, termed CYP19. Aromatase is a microsomal protein that is found throughout the vertebrate phylum, but the human gene is unique compared with the rest of its superfamily.The aromatase reaction employs 3 moles of oxygen and 3 moles of NADPH for every mole of steroid substrate metabolized. Aromatase shares a number of structural features common to all cytochrome P450 species.Aromatase is most widely known for its roles in reproduction and reproductive system diseases, and as a target for inhibitor therapy in estrogen-sensitive diseases including cancer, endometriosis, and leiomyoma.

References

1.Blakemore J,et al. Physiology (Bethesda). 2016 Jul;31(4):258-69

Endocrinology/Hormones

5-HT Receptor(330) AChR(224) Adrenergic Receptor(69) AhR(24) Androgen Receptor (AR)(83) Annexin A(6) Aromatase(9) ATPase(42) CaMK(21) COX(0) Estrogen Receptor/ERR(136) GPR(0) GR(49) MRP(9) Opioid Receptor(86) RAAS(45) Reductase(21) THR(18)