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Aromatase

Aromatase is the sole member of family 19 of the P450 superfamily of enzymes, termed CYP19. Aromatase is a microsomal protein that is found throughout the vertebrate phylum, but the human gene is unique compared with the rest of its superfamily.The aromatase reaction employs 3 moles of oxygen and 3 moles of NADPH for every mole of steroid substrate metabolized. Aromatase shares a number of structural features common to all cytochrome P450 species.Aromatase is most widely known for its roles in reproduction and reproductive system diseases, and as a target for inhibitor therapy in estrogen-sensitive diseases including cancer, endometriosis, and leiomyoma.

References

1.Blakemore J,et al. Physiology (Bethesda). 2016 Jul;31(4):258-69

Endocrinology/Hormones

5-HT Receptor(228) AChR(149) Adrenergic Receptor(69) AhR(16) Androgen Receptor (AR)(57) Annexin A(6) Aromatase(8) ATPase(20) CaMK(15) COX(0) Estrogen Receptor/ERR(91) GPR(0) GR(48) MRP(5) Opioid Receptor(44) RAAS(19) Reductase(9) THR(10)