β2AR-IN-15

CAS No. 2088234-50-6

β2AR-IN-15 ( —— )

Catalog No. M13255 CAS No. 2088234-50-6

An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    β2AR-IN-15
  • Note
    Research use only, not for human use.
  • Brief Description
    An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM.
  • Description
    An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM; binds in proximity to the G-protein binding site on the cytosolic surface of the β2AR; inhibits cAMP production through the β2AR, but not that mediated by other Gs-coupled receptors; also similarly inhibits β-arrestin recruitment to the activated β2AR.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    Adrenergic Receptor
  • Recptor
    Adrenergic Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2088234-50-6
  • Formula Weight
    647.61
  • Molecular Formula
    C34H39BrN4O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    4-((2S)-3-(((S)-3-(3-bromophenyl)-1-(methylamino)-1-oxopropan-2-yl)amino)-2-(2-cyclohexyl-2-phenylacetamido)-3-oxopropyl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ahn S, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713.
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