β2AR-IN-15 ( —— )

Catalog No. M13255 CAS No. 2088234-50-6

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Product Name

β2AR-IN-15
Note

Research use only, not for human use.
Brief Description

An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM.
Description

An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM; binds in proximity to the G-protein binding site on the cytosolic surface of the β2AR; inhibits cAMP production through the β2AR, but not that mediated by other Gs-coupled receptors; also similarly inhibits β-arrestin recruitment to the activated β2AR.
Synonyms

——
Pathway

Angiogenesis
Target

Adrenergic Receptor
Recptor

Adrenergic Receptor
Research Area

——
Indication

——

CAS Number

2088234-50-6
Formula Weight

647.61
Molecular Formula

C34H39BrN4O4
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

4-((2S)-3-(((S)-3-(3-bromophenyl)-1-(methylamino)-1-oxopropan-2-yl)amino)-2-(2-cyclohexyl-2-phenylacetamido)-3-oxopropyl)benzamide

1. Ahn S, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713.

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