β2AR-IN-15
CAS No. 2088234-50-6
β2AR-IN-15 ( —— )
Catalog No. M13255 CAS No. 2088234-50-6
An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product Nameβ2AR-IN-15
-
NoteResearch use only, not for human use.
-
Brief DescriptionAn allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM.
-
DescriptionAn allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM; binds in proximity to the G-protein binding site on the cytosolic surface of the β2AR; inhibits cAMP production through the β2AR, but not that mediated by other Gs-coupled receptors; also similarly inhibits β-arrestin recruitment to the activated β2AR.
-
Synonyms——
-
PathwayAngiogenesis
-
TargetAdrenergic Receptor
-
RecptorAdrenergic Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2088234-50-6
-
Formula Weight647.61
-
Molecular FormulaC34H39BrN4O4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name4-((2S)-3-(((S)-3-(3-bromophenyl)-1-(methylamino)-1-oxopropan-2-yl)amino)-2-(2-cyclohexyl-2-phenylacetamido)-3-oxopropyl)benzamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ahn S, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713.
molnova catalog
related products
-
Arformoterol Tartrat...
Arformoterol Tartrate is the tartrate salt of arformoterol. Arformoterol is a long-acting beta-2 adrenergic agonist with bronchodilator activity.
-
Dihydrochelerythrine
Dihydrochelerythrine is nontoxic up to 5μM concentration. Dihydrochelerythrine has antifungal activity against pathogenic plant fungi.
-
TAK-259 hydrochlorid...
A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively.