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β2AR-IN-15
CAS No. 2088234-50-6
β2AR-IN-15( —— )
Catalog No. M13255 CAS No. 2088234-50-6
An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Nameβ2AR-IN-15
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NoteResearch use only, not for human use.
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Brief DescriptionAn allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM.
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DescriptionAn allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM; binds in proximity to the G-protein binding site on the cytosolic surface of the β2AR; inhibits cAMP production through the β2AR, but not that mediated by other Gs-coupled receptors; also similarly inhibits β-arrestin recruitment to the activated β2AR.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetAdrenergic Receptor
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RecptorAdrenergic Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2088234-50-6
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Formula Weight647.614
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Molecular FormulaC34H39BrN4O4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name4-((2S)-3-(((S)-3-(3-bromophenyl)-1-(methylamino)-1-oxopropan-2-yl)amino)-2-(2-cyclohexyl-2-phenylacetamido)-3-oxopropyl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ahn S, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713.
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