AGN192836 ( AGN 192836 )

Catalog No. M12609 CAS No. 171102-29-7

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HNMR

HPLC

MSDS

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Product Name

AGN192836
Note

Research use only, not for human use.
Brief Description

AGN192836 (AGN 192836) is a potent, selective α2 adrenergic (alpha 2-adrenoceptor) agonist with EC50 of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.
Description

AGN192836 (AGN 192836) is a potent, selective α2 adrenergic (alpha 2-adrenoceptor) agonist with EC50 of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively; displays 1200-, 50- and 10-fols selectivity for the α2A-receptor, α2B-receptor, and α2C-receptors relative to the α2C-receptors; demonstrates effectivity for the reduction of intraocular pressure and for the reduction of blood pressure in vivo.
Synonyms

AGN 192836
Pathway

Angiogenesis
Target

Adrenergic Receptor
Recptor

Adrenergic Receptor
Research Area

Cardiovascular Disease
Indication

——

CAS Number

171102-29-7
Formula Weight

231.26
Molecular Formula

C12H13N3O2
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=C(C=CC2=C1OCCO2)NC3=NC=CN3
Chemical Name

N-(2,3-Dihydro-5-methyl-1,4-benzodioxin-6-yl)-1H-imidazol-2-amine

1. Munk SA, et al. J Med Chem. 1997 Jan 3;40(1):18-23.

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