rac-BHFF( —— )

Catalog No. M17212 CAS No. 123557-91-5

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Product Name

rac-BHFF
Note

Research use only, not for human use.
Brief Description

Rac-BHFF is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively).
Description

Rac-BHFF is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). It exhibits anxiolytic activity in vivo and is orally active.
In Vitro

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In Vivo

rac-BHFF has anxiolytic-like properties in stress-induced hyperthermia (SIH) in mice.rac-BHFF (3, 10, 30 and 100?mg/kg, p.o.) reverses SIH and high significance was reached for 100?mg?kg?1 (P<0.001). Animal Model:Male NMRI mice (20-25?g).Dosage:3, 10, 30 or 100 mg/kg.Administration:P.O..Result:Significantly increased the LRR effects of a subthreshold dose of baclofen at doses of 3?mg/kg and above.
Synonyms

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Pathway

Apoptosis
Target

PERK
Recptor

GABAB
Research Area

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Indication

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1.Krishnamurthy S,et al.,Acta Crystallogr E Crystallogr Commun. 2015 Jul 1; 71(Pt 7): o449–o450.

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