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pocapavir
CAS No. 146949-21-5
pocapavir ( SCH-48973; SCH48973; SCH 48973; V074 )
Catalog No. M17315 CAS No. 146949-21-5
Pocapavir is an investigational enterovirus (EV) capsid inhibitor.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 102 | In Stock |
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| 25MG | 192 | In Stock |
|
| 50MG | 335 | In Stock |
|
| 100MG | 537 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Namepocapavir
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NoteResearch use only, not for human use.
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Brief DescriptionPocapavir is an investigational enterovirus (EV) capsid inhibitor.
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DescriptionPocapavir, also known as SCH-48973 and V-073, is a potent, selective, antienterovirus agent. SCH-48973 had antiviral activity (50% inhibitory concentrations [IC50s]) of 0.02 to 0.11 microg/ml, with no detectable cytotoxicity at 50 microg/ml. SCH-48973 inhibited 80% of 154 recent human enterovirus isolates at an IC50 of 0.9 microg/ml. The affinity constant (Ki) for SCH-48973 binding to poliovirus was 8.85 x 10(-8) M. SCH-48973 demonstrated efficacy in a murine poliovirus model of enterovirus disease. SCH-48973 represents a potential candidate for therapeutic intervention against enterovirus infections.
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SynonymsSCH-48973; SCH48973; SCH 48973; V074
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PathwayAutophagy
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TargetAutophagy
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RecptorAntiviral
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Research Area——
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Indication——
Chemical Information
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CAS Number146949-21-5
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Formula Weight423.72
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Molecular FormulaC21H17Cl3O3
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Purity98%
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SolubilityDMSO : 100 mg/mL. 236.00 mM; H2O : < 0.1 mg/mL
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SMILESCOc1ccc(OCc2ccc(COc3c(Cl)cccc3Cl)cc2)c(Cl)c1
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Chemical Name1,3-dichloro-2-((4-((2-chloro-4-methoxyphenoxy)methyl)benzyl)oxy)benzene
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Collett MS, et al. Antiviral Activity of Pocapavir in a Randomized, Blinded, Placebo-Controlled Human Oral Poliovirus Vaccine Challenge Model. J Infect Dis. 2017 Feb 1;215(3):335-343.
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